Hemodynamic Parameters Predict Outcome in PH-HFpEF

Share this content:
Hemodynamic Parameters Predict Outcome in PH-HFpEF
Hemodynamic Parameters Predict Outcome in PH-HFpEF

FRIDAY, March 16, 2018 (HealthDay News) -- The hemodynamic parameters transpulmonary gradient, pulmonary vascular resistance, and diastolic pulmonary gradient are associated with mortality and cardiac hospitalization in pulmonary hypertension (PH) in patients with heart failure with preserved ejection fraction (HFpEF), according to a study published online March 14 in JAMA Cardiology.

Rebecca R. Vanderpool, Ph.D., from the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, and colleagues examined the hemodynamic characteristics and outcomes of PH-HFpEF in participants who had a right heart catheterization. Hemodynamic catheterization data were linked to the clinical data repository for all inpatient and outpatient encounters across a health system. Data were included for 19,262 procedures in 10,023 participants.

The researchers found that 25.8 percent of the participants had PH-HFpEF. At years one and five, mortality was 23.6 and 48.2 percent, respectively. Cardiac hospitalizations occurred in 28.1 and 47.4 percent at one and five years, respectively. Using clinically defined cut-offs for transpulmonary gradient (>12 mm Hg), pulmonary vascular resistance (3 Woods units), and diastolic pulmonary gradient (≥7 mm Hg), the frequency of precapillary PH was 12.6, 8.8, and 3.5 percent, respectively. Mortality and cardiac hospitalizations were predicted by transpulmonary gradient, pulmonary vascular resistance, and diastolic pressure gradient.

"Transpulmonary gradient, pulmonary vascular resistance, and diastolic pulmonary gradient are all associated with mortality and cardiac hospitalizations," the authors write.

Three authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: U.S. Abortion Rate Declined 24 Percent From 2006 to 2015

CDC: U.S. Abortion Rate Declined 24 Percent From ...

Abortions among women ages 15-44 fell 26 percent, from 15.9 to 11.8 abortions per 1,000 women

U of Maryland Student Dies of Adenovirus-Related Illness

U of Maryland Student Dies of Adenovirus-Related Illness

CDC testing of specimen revealed adenovirus type 7, a strain that may cause more severe illness

FDA Approves Drug to Treat Rare Immune Disease

FDA Approves Drug to Treat Rare Immune Disease

Gamifant first drug to be approved specifically for primary hemophagocytic lymphohistiocytosis

is free, fast, and customized just for you!




Already a member?

Sign In Now »