Haloperidol for Delirium in Critically Ill No Help for Survival

Share this content:
Haloperidol for Delirium in Critically Ill No Help for Survival
Haloperidol for Delirium in Critically Ill No Help for Survival

THURSDAY, Feb. 22, 2018 (HealthDay News) -- For critically ill adults at high risk of delirium, prophylactic haloperidol does not improve survival at 28 days compared with placebo, according to a study published online Feb. 20 in the Journal of the American Medical Association.

In a randomized trial, Mark van den Boogaard, Ph.D., from the Radboud University Medical Center in Nijmegen, Netherlands, and colleagues examined whether prophylactic use of haloperidol improves survival among critically ill adults at high risk of delirium. A total of 1,789 critically ill adults treated at 21 intensive care units (ICUs) were randomized to receive prophylactic treatment three times daily with 1 mg or 2 mg of haloperidol (350 and 732 patients, respectively), or placebo (707 patients).

Due to futility, the 1 mg haloperidol group was stopped prematurely. The researchers observed no significant difference in the median days that patients survived in 28 days (28 days for haloperidol versus 28 days for placebo). There was no statistically significant difference in any of the 15 secondary outcomes, including delirium incidence, delirium-free and coma-free days, and duration of mechanical ventilation, ICU, and hospital length of stay. There was no difference between the groups in the number of reported adverse events.

"These findings do not support the use of prophylactic haloperidol for reducing mortality in critically ill adults," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Identifies Drugs Frequently Involved in Drug Overdose Deaths

CDC Identifies Drugs Frequently Involved in Drug Overdose ...

Oxycodone, heroin, and fentanyl ranked first in 2011, 2012-2015, 2016; cocaine ranked second or third

2017 Saw Slowing in National Health Care Spending

2017 Saw Slowing in National Health Care Spending

Slower growth in health care spending mainly due to use and intensity of goods and services

Inflammatory Bowel Disease, Prostate Cancer Linked

Inflammatory Bowel Disease, Prostate Cancer Linked

At age 60, men with inflammatory bowel disease have higher values of prostate-specific antigen

is free, fast, and customized just for you!




Already a member?

Sign In Now »