Greater Weight Loss Linked to Superior Outcomes in Knee OA

Share this content:
Greater Weight Loss Linked to Superior Outcomes in Knee OA
Greater Weight Loss Linked to Superior Outcomes in Knee OA

MONDAY, June 18, 2018 (HealthDay News) -- For overweight and obese older adults with knee osteoarthritis (OA), greater weight loss is associated with superior clinical and mechanistic outcomes, according to a study published online June 18 in Arthritis Care & Research.

Stephen P. Messier, Ph.D., from Wake Forest University in Winston-Salem, N.C., and colleagues conducted a secondary analysis of the Intensive Diet and Exercise for Arthritis randomized controlled clinical trial, which included 240 overweight and obese older community-dwelling adults with pain and radiographic knee OA. Participants were classified according to weight loss achieved over an 18-month period: <5 percent, ≥5 percent, ≥10 percent, and ≥20 percent.

The researchers found that for pain, function, six-minute walk distance, physical and mental health-related quality of life (HRQOL), knee joint compressive force, and interleukin-6, there were significant dose responses to weight loss. Superior clinical and mechanistic outcomes were seen with greater weight loss, with the ≥20 percent weight loss group differentiating itself on all measures versus the <5 percent and ≥5 percent weight loss groups. Compared with the ≥10 percent weight loss group, the ≥20 percent weight loss group had 25 percent less pain and better function, as well as significantly better physical HRQOL.

"A 10 percent weight loss is the established target recommended by the National Institutes of Health as an initial weight loss for overweight and obese adults," Messier said in a statement. "The importance of our study is that a weight loss of 20 percent or greater -- double the previous standard -- results in better clinical outcomes and is achievable without surgical or pharmacologic intervention."

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA: Gout Drug Uloric Increases Risk of Death

FDA: Gout Drug Uloric Increases Risk of Death

Medication is associated with increased risk of heart-related death and death from all causes

Since Early 2000s, Overdose Death Rates Are Highest in U.S.

Since Early 2000s, Overdose Death Rates Are Highest ...

U.S. was not an outlier in terms of drug overdose mortality prior to the early 2000s

National Health Spending Set to Increase 5.5 Percent Annually

National Health Spending Set to Increase 5.5 Percent ...

Long-observed demographic and economic factors expected to drive growth in health spending

is free, fast, and customized just for you!




Already a member?

Sign In Now »