Graft Survival Similar for Kidneys From Octogenarians

This article originally appeared here.
Share this content:
Graft Survival Similar for Kidneys From Octogenarians
Graft Survival Similar for Kidneys From Octogenarians

TUESDAY, Aug. 15, 2017 (HealthDay News) -- Graft survival is similar for recipients of kidneys from >80-year-old donors and donors aged ≤60 years, according to a study published online Aug. 9 in the American Journal of Transplantation.

Piero Ruggenenti, M.D., from the Clinical Research Centre for Rare Diseases Aldo e Cele Daccò in Bergamo, Italy, and colleagues compared graft survival for 37 recipients of one or two histologically evaluated kidneys from >80-year-old donors with 198 reference-recipients of nonhistologically evaluated single grafts from ≤60-year-old donors.

The researchers found that two recipients (5.4 percent) and 10 reference-recipients (5.1 percent) required dialysis over a median of 25 months (crude and donor age- and sex-adjusted hazard ratios, 1.55 [95 percent confidence interval, 0.34 to 7.12; P = 0.576] and 1.41 [95 percent confidence interval, 0.1 to 19.54; P = 0.798]). Similar outcomes were confirmed in shared frailty analyses in a 1-to-2 propensity score study comparing recipients with 74 reference-recipients matched by center, year, and donor and recipient sex and age. Over 84-month follow-up, serum creatinine was similar across groups. Recipients had shorter waiting times than reference-recipients and matched reference-recipients (7.5 versus 36 and 40 months, respectively; both P < 0.0001). Similar adverse events were seen across groups.

"Biopsy-guided allocation of kidneys from octogenarian donors permits further expansion of the donor-organ pool and faster access to a kidney transplant, without increasing the risk of premature graft failure," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Global Prevalence of Insufficient Activity 27.5 Percent

Global Prevalence of Insufficient Activity 27.5 Percent

Levels of insufficient physical activity stable between 2001, 2016; increase seen in high-income countries

HTN Tx Intensification Common Upon Discharge in U.S. Vets

HTN Tx Intensification Common Upon Discharge in U.S. ...

Fourteen percent of older adults admitted to hospital for non-cardiac conditions had intensification of tx

Quarterly Canakinumab Reduces Risk for Gout Attacks

Quarterly Canakinumab Reduces Risk for Gout Attacks

Doesn't affect serum uric acid levels over time, but targets interleukin-1β

is free, fast, and customized just for you!




Already a member?

Sign In Now »