Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes

Share this content:
Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes
Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Oral semaglutide is associated with better glycemic control than placebo among type 2 diabetes patients with insufficient glycemic control, according to a study published online Oct. 17 in the Journal of the American Medical Association.

Melanie Davies, M.D., from the University of Leicester in the United Kingdom, and colleagues randomized 632 patients with insufficient glycemic control using diet and exercise alone or a stable dose of metformin to semaglutide or placebo; 583 patients completed the phase 2 trial.

The researchers found that there were decreases in the mean change in HbA1c level from baseline to week 26 with oral semaglutide (dosage-dependent range, −0.7 to −1.9 percent), subcutaneous semaglutide (−1.9 percent), and placebo (−0.3 percent); oral semaglutide reductions were significant compared with placebo.

"Among patients with type 2 diabetes, oral semaglutide resulted in better glycemic control than placebo over 26 weeks," the authors conclude. "These findings support phase 3 studies to assess longer-term and clinical outcomes, as well as safety."

Several authors in the Davies study disclosed financial ties to the pharmaceutical industry, including Novo Nordisk, which partially funded the study.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »