Glyburide Not Noninferior to Insulin for Gestational Diabetes

Share this content:
Glyburide Not Noninferior to Insulin for Gestational Diabetes
Glyburide Not Noninferior to Insulin for Gestational Diabetes

TUESDAY, May 1, 2018 (HealthDay News) -- For women with gestational diabetes, glyburide is not noninferior to insulin, according to a study published in the May 1 issue of the Journal of the American Medical Association.

Marie-Victoire Sénat, M.D., Ph.D., from the University of Paris-Sud, and colleagues compared oral glyburide with subcutaneous insulin for prevention of perinatal complications in newborns of women with gestational diabetes in a multicenter noninferiority randomized trial. A total of 914 women with singleton pregnancies and gestational diabetes diagnosed between 24 and 34 weeks of gestation who required pharmacologic treatment after 10 days of dietary intervention were randomized to glyburide or insulin (460 and 454 participants, respectively). The noninferiority margin was set at 7 percent.

In a per-protocol analysis, 367 women randomized to glyburide and 442 to insulin and their neonates were analyzed. The researchers found that the frequency of the primary outcome of a composite criterion, including macrosomia, neonatal hypoglycemia, and hyperbilirubinemia, was 27.6 and 23.4 percent in the glyburide and insulin groups, respectively (difference, 4.2 percent; one-sided 97.5 percent confidence interval, −∞ to 10.5 percent; P = 0.19).

"This study of women with gestational diabetes failed to show that use of glyburide compared with subcutaneous insulin does not result in a greater frequency of perinatal complications," the authors write. "These findings do not justify the use of glyburide as a first-line treatment."

One author disclosed financial ties to Ferring Laboratories.

Abstract/Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

8 More U.S. Communities to Be Assessed for PFAS Toxin Exposure

8 More U.S. Communities to Be Assessed for ...

Assessments will lay groundwork for future study of the health effects of perfluoroalkyl, polyfluoroalkyl

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

Proposed rule will help consumers better understand what the sunscreens they are buying can actually do

U.S. Agencies Probing Johnson  Johnson Over Asbestos in Talc

U.S. Agencies Probing Johnson & Johnson Over Asbestos ...

Company has faced lawsuits linking its body powders with ovarian cancer or mesothelioma

is free, fast, and customized just for you!




Already a member?

Sign In Now »