Genetic Variants Tied to Type 1 Diabetes Heterogeneity

Share this content:
Genetic Variants Tied to Type 1 Diabetes Heterogeneity
Genetic Variants Tied to Type 1 Diabetes Heterogeneity

MONDAY, Nov. 27, 2017 (HealthDay News) -- Transcription factor 7 like 2 (TCF7L2) genetic variants contribute to phenotypic heterogeneity of type 1 diabetes, according to a study published online Oct. 12 in Diabetes Care.

Maria J. Redondo, M.D., Ph.D., from Texas Children's Hospital in Houston, and colleagues investigated the relationship between type 2 diabetes-associated TCF7L2 single nucleotide polymorphisms and immunologic and metabolic characteristics at type 1 diabetes diagnosis among 810 patients with newly diagnosed autoimmune type 1 diabetes (median age, 13.6 years).

The researchers found that the rs4506565 variant was a significant independent factor for expressing a single autoantibody at diagnosis, instead of multiple autoantibodies (odds ratio [OR], 1.66; P = 0.024). This association was only significant in participants ≥12 years old (OR, 2.12; P = 0.003) compared to younger ones (P = 0.73). There was a significant association between the rs4506565 variant and both higher C-peptide area under the curve (P = 0.008) and lower mean glucose area under the curve (P = 0.0127). Similar results were seen for the rs7901695 variant.

"Carriers of the TCF7L2 variant had a milder immunological and metabolic phenotype at type 1 diabetes diagnosis, which could be partly driven by type 2 diabetes-like pathogenic mechanisms," the authors write.

Abstract/ Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Global Prevalence of Insufficient Activity 27.5 Percent

Global Prevalence of Insufficient Activity 27.5 Percent

Levels of insufficient physical activity stable between 2001, 2016; increase seen in high-income countries

HTN Tx Intensification Common Upon Discharge in U.S. Vets

HTN Tx Intensification Common Upon Discharge in U.S. ...

Fourteen percent of older adults admitted to hospital for non-cardiac conditions had intensification of tx

Quarterly Canakinumab Reduces Risk for Gout Attacks

Quarterly Canakinumab Reduces Risk for Gout Attacks

Doesn't affect serum uric acid levels over time, but targets interleukin-1β

is free, fast, and customized just for you!




Already a member?

Sign In Now »