Gene Therapy, Visual Stimulation Aids Vision Restoration

This article originally appeared here.
Share this content:
Gene Therapy, Visual Stimulation Aids Vision Restoration
Gene Therapy, Visual Stimulation Aids Vision Restoration

TUESDAY, July 12, 2016 (HealthDay News) -- A combination of gene therapy and visual stimulation prompts partial regrowth of the optic nerves, restoring some communication between the brain and the eye, according to an experimental study published online July 11 in Nature Neuroscience.

Andrew Huberman, Ph.D., an associate professor of neurobiology at the Stanford University School of Medicine in Palo Alto, Calif., and colleagues used forceps to crush the optic nerve leading to one eye in a group of laboratory mice. They then set about trying to repair the nerve they'd damaged, using different therapies.

Partial regeneration of the optic nerve occurred when researchers used gene therapy to stimulate the mammalian target of rapamycin pathway. The research team also had some success in promoting optic nerve regeneration through visual stimulation, where the mice used only their damaged eye to watch a series of high-contrast moving bars. That therapy promoted some nerve regrowth, the researchers said.

But neither approach alone could re-establish the link between brain and eye. "We found that the neurons would regrow, but not very far," Huberman told HealthDay. "They would grow towards the brain, but they couldn't reconnect with the brain." However, combining both gene therapy and visual stimulation caused a small part of the optic nerve to fully regenerate a connection between the eye and the brain, the researchers found. "When we did that, we saw an incredible synergistic effect," Huberman said. "The axons not only regrew, but they grew very fast and they regrew all the way back into the brain."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »