Functional Imaging Beneficial for Analgesic Drug Development

Share this content:
Functional Imaging Beneficial for Analgesic Drug Development
Functional Imaging Beneficial for Analgesic Drug Development

FRIDAY, Feb. 12, 2016 (HealthDay News) -- Functional magnetic resonance imaging with central sensitization can be used in early human drug development, according to a study published in the January issue of Anesthesiology.

Vishvarani Wanigasekera, D.Phil., from the University of Oxford in the United Kingdom, and colleagues examined the utility of functional magnetic resonance imaging with capsaicin-induced central sensitization for differentiating an effective analgesic (gabapentin) from an ineffective analgesic and from placebo. Data were included for single oral doses in a double-blind phase I trial involving 24 participants.

The researchers found that suppression of the secondary mechanical hyperalgesia-evoked neural response in right nucleus cuneiformis and left posterior insular cortex and secondary somatosensory cortex was seen with gabapentin only. During central sensitization, suppression of the resting-state functional connectivity between the thalamus and secondary somatosensory cortex was also seen with gabapentin only, and was dependent on the plasma gabapentin level. A statistically significant difference between placebo and gabapentin was detected with a probability of ≥0.8 in a power analysis using neural activity from the left posterior insula and right nucleus cuneiformis. This was attenuated to ≤0.6 when using subjective pain ratings.

"Functional imaging with central sensitization can be used as a sensitive mechanism-based assay to guide go/no-go decisions on selecting analgesics effective in neuropathic pain in early human drug development," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Bayer Stops U.S. Sale of Essure Birth Control Implant

Bayer Stops U.S. Sale of Essure Birth Control ...

Problems with device include chronic pain and perforations of the uterus and fallopian tubes

C.S. Mott Poll Addresses Child Safety at Amusement Parks

C.S. Mott Poll Addresses Child Safety at Amusement ...

2016 saw U.S. emergency departments deal with 30,000 injuries linked to amusement parks, carnivals

Greening Vacant Land Improves Neighborhood Mental Health

Greening Vacant Land Improves Neighborhood Mental Health

Cleaning up vacant lots in resource-limited urban settings can aid residents' mental health

is free, fast, and customized just for you!




Already a member?

Sign In Now »