Fremanezumab Linked to Fewer Monthly Migraine Days

Share this content:
Fremanezumab Linked to Fewer Monthly Migraine Days
Fremanezumab Linked to Fewer Monthly Migraine Days

WEDNESDAY, May 16, 2018 (HealthDay News) -- For patients with episodic migraine, fremanezumab is associated with a reduction in the mean number of monthly migraine days, according to a study published in the May 15 issue of the Journal of the American Medical Association.

David W. Dodick, M.D., from Mayo Clinic Arizona in Phoenix, and colleagues conducted a randomized controlled trial at 123 sites in nine countries. Participants, aged 18 to 70 years with episodic migraine, were randomized to receive subcutaneous monthly dosing of fremanezumab (290 participants, 225 mg at baseline and weeks four and eight), a single higher dose of fremanezumab (291 patients, 675 mg at baseline, placebo at weeks four and eight), or placebo (294 participants); 90.4 percent of participants completed the trial.

The researchers found that over 12 weeks, mean migraine days per month decreased from 8.9 to 4.9 days, from 9.2 to 5.3 days, and from 9.1 to 6.5 days in the fremanezumab monthly dosing group, the fremanezumab single-higher-dose group, and the placebo group, respectively. The difference with monthly dosing and single dosing versus placebo was −1.5 and −1.3 days, respectively. Injection site erythema, injection site induration, diarrhea, anxiety, and depression were the most common adverse events that led to discontinuation.

"Further research is needed to assess effectiveness against other preventive medications," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Teva Pharmaceuticals, which manufactures fremanezumab and funded the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »