FPG + A1C Best Detects Abnormal Glucose Tolerance in Africans

This article originally appeared here.
Share this content:
FPG + A1C Best Detects Abnormal Glucose Tolerance in Africans
FPG + A1C Best Detects Abnormal Glucose Tolerance in Africans

FRIDAY, Nov. 7, 2014 (HealthDay News) -- For U.S.-based Africans, fasting plasma glucose (FPG) and hemoglobin A1c (A1C) in combination have higher sensitivity for abnormal glucose tolerance than either test alone, with no difference by variant hemoglobin status, according to a study published online Oct. 22 in Diabetes Care.

Anne E. Sumner, M.D., from the National Institutes of Health in Bethesda, Md., and colleagues examined the sensitivities of FPG ≥5.6 mmol/L, A1C ≥5.7 percent, and FPG combined with A1C for detection of abnormal glucose tolerance in U.S.-based Africans. Data were obtained from 216 African immigrants who underwent an oral glucose tolerance test.

The researchers found that 21 percent of the participants had variant hemoglobin. Thirty-three percent had abnormal glucose tolerance. The sensitivities of FPG were 32, 32, and 33 percent, respectively, for the total, normal, and variant hemoglobin groups. For A1C, the corresponding sensitivities were 53, 54, and 47 percent. The sensitivities were 64, 63, and 67 percent, respectively, for FPG and A1C combined. There was no variation in the sensitivities for FPG, A1C, and the combination based on hemoglobin status (all P > 0.6). Sensitivity was higher for A1C than for FPG and for the combination versus either test alone in the entire cohort (all P values ≤ 0.01).

"For the diagnosis of abnormal glucose tolerance in Africans, the sensitivity of A1C combined with FPG is significantly superior to either test alone," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wildfire Smoke Causing Poor Air Quality in U.S. Pacific Northwest

Wildfire Smoke Causing Poor Air Quality in U.S. ...

Air pollution advisories, air quality alerts issued for Washington, Oregon

Odds of Death Up With Exposure to Pregabalin, Opioids

Odds of Death Up With Exposure to Pregabalin, ...

Dose-response association with highest odds of opioid-related death with high-dose pregabalin

NYU Becomes First Medical School to Cover All Tuition

NYU Becomes First Medical School to Cover All ...

Full-tuition scholarships, regardless of need, offered to all new and current medical students

is free, fast, and customized just for you!




Already a member?

Sign In Now »