Fingolimod Cuts Multiple Sclerosis Relapses in Pediatric Patients

Share this content:
Fingolimod Cuts Multiple Sclerosis Relapses in Pediatric Patients
Fingolimod Cuts Multiple Sclerosis Relapses in Pediatric Patients

WEDNESDAY, Sept. 12, 2018 (HealthDay News) -- Among pediatric patients with relapsing multiple sclerosis, fingolimod is associated with a lower rate of relapse but a higher rate of serious adverse events than interferon beta-1a, according to a study published in the Sept. 13 issue of the New England Journal of Medicine.

Tanuja Chitnis, M.D., from Massachusetts General Hospital in Boston, and colleagues compared outcomes in patients aged 10 to 17 years with relapsing multiple sclerosis who were randomized to receive fingolimod (107 participants) or interferon beta-1a (108 participants) for up to two years.

The researchers found that the adjusted annualized relapse rate was 0.12 with fingolimod and 0.67 with interferon beta-1a. The annualized rate of new or newly enlarged lesions on T2-weighted magnetic resonance imaging was 4.39 with fingolimod and 9.27 with interferon beta-1a. Adverse events occurred in 88.8 percent of patients receiving fingolimod and 95.3 percent receiving interferon beta-1a. Serious adverse events occurred in 18 patients (16.8 and 6.5 percent, respectively). These serious adverse events included seizures (four patients), infection (four patients), and leukopenia (two patients) in the fingolimod group and infection (two patients) and supraventricular tachycardia (one patient) in the interferon beta-1a group.

"Longer studies are required to determine the durability and safety of fingolimod in pediatric multiple sclerosis," the authors write.

Several authors disclosed financial ties to Novartis, which manufactures fingolimod and funded the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Compression Collar May Protect Brain of Female Soccer Players

Compression Collar May Protect Brain of Female Soccer ...

No white matter changes among female high school soccer athletes who wore compression collar

Fertility Rates Down for Each Urbanization Level 2007 to 2017

Fertility Rates Down for Each Urbanization Level 2007 ...

Fertility rates decreased from 2007 to 2017 with larger decreases in metro versus rural counties

Lung Cancer Deaths 28 Lower in California Than Rest of U.S.

Lung Cancer Deaths 28% Lower in California Than ...

Among those aged 18 to 35, California has had larger drops in smoking initiation, intensity, more quitting

is free, fast, and customized just for you!




Already a member?

Sign In Now »