Fewer SIDS Cases Result From Genetic Heart Disease Causes

Share this content:
Fewer SIDS Cases Result From Genetic Heart Disease Causes
Fewer SIDS Cases Result From Genetic Heart Disease Causes

THURSDAY, March 15, 2018 (HealthDay News) -- Genetic heart diseases (GHDs) cause fewer cases of sudden infant death syndrome (SIDS) than previously thought, according to a study published in the March 20 issue of the Journal of the American College of Cardiology.

David J. Tester, from the Mayo Clinic in Rochester, Minn., and colleagues conducted whole exome sequencing and targeted analysis of 90 GHD-susceptibility genes in a cohort of 419 unrelated SIDS cases (257 male; average age 2.7 months).

The researchers found that 53 SIDS cases (12.6 percent) had at least one "potentially informative" GHD-associated variant. For mixed-European ancestry cases, the yield was 14.9 percent (21 of 141), and for European ancestry SIDS cases it was 11.5 percent (32 of 278). A potentially informative GHD-associated variant was more likely in infants older than 4 months. When combining all four major cardiac channelopathy genes (KCNQ1, KCNH2, SCN5A, and RYR2), ultra-rare, nonsynonymous variants were significantly overrepresented in European SIDS cases versus European control subjects (P = 0.013). Only 4.3 percent of SIDS cases hosted a "pathogenic" or "likely pathogenic" variant, as defined by guidelines from the American College of Medical Genetics.

"Consistent with previous studies, ultra-rare, nonsynonymous variants within the major cardiac channelopathy-associated genes were overrepresented in SIDS cases in infants of European ethnicity," the authors write. "These findings have major implications for the investigation of SIDS cases and families."

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to ...

Increased dementia risk for those with abstinence or with drinking >14 units alcohol/week in midlife

Intervention Cuts Risk for HIV in Young Transgender Women

Intervention Cuts Risk for HIV in Young Transgender ...

Intervention group had greater reduction in condomless sex acts versus standard of care group

Trauma Surgery Association IDs Steps to Curb Firearm Violence

Trauma Surgery Association IDs Steps to Curb Firearm ...

14 recommendations include actions to be taken by federal government, professional bodies

is free, fast, and customized just for you!




Already a member?

Sign In Now »