FDA Safety Announcement Affected Bisphosphonate Use

This article originally appeared here.
Share this content:
FDA Safety Announcement Affected Bisphosphonate Use
FDA Safety Announcement Affected Bisphosphonate Use

WEDNESDAY, March 16, 2016 (HealthDay News) -- A U.S. Food and Drug Administration safety announcement relating to atrial fibrillation risk associated with bisphosphonates correlated with a reduction in bisphosphonate use, according to a study published online March 11 in the Journal of Bone and Mineral Research.

Seoyoung C. Kim, M.D., Sc.D., from Brigham and Women's Hospital in Boston, and colleagues used claims data from a U.S. commercial health plan to examine the impact of three FDA drug safety announcements on the use of bisphosphonates (in 2005 relating to osteonecrosis of the jaw; in 2007 relating to atrial fibrillation; and in 2010 relating to atypical femur fracture). Data were obtained for 22,598 patients with hip fracture from 2004 to 2013.

The researchers found that bisphosphonate use decreased from 15 percent in 2004 to 3 percent in the last quarter of 2013. There was a 4 percent increase in the odds of bisphosphonate use every quarter prior to the 2007 announcement; a 4 percent decrease in the odds of bisphosphonate use was seen after the announcement. The 2007 announcement correlated with a significant decline in the rate of change of bisphosphonate use (P < 0.001). The odds of bisphosphonate use continued to decrease by 4 percent per quarter after the 2010 announcement.

"The FDA safety announcement related to atrial fibrillation in 2007 was significantly associated with a decrease in bisphosphonate use among patients with hip fracture," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »