Extended-Release Niacin Lowers ApoB-48 Concentration in T2DM

This article originally appeared here.
Share this content:
Extended-Release Niacin Lowers ApoB-48 Concentration in T2DM
Extended-Release Niacin Lowers ApoB-48 Concentration in T2DM

FRIDAY, Jan. 8, 2016 (HealthDay News) -- For patients with type 2 diabetes, a statin plus extended-release niacin (ERN) lowers apolipoprotein B-48 (apoB-48) concentration compared to a statin alone, according to a study published online Dec. 18 in Diabetes, Obesity and Metabolism.

Jing Pang, from the University of Western Australia in Perth, and colleagues examined the effect of ERN on apoB-48 kinetics in 12 statin-treated men with type 2 diabetes. Participants were randomly allocated to receive 12 weeks of rosuvastatin (R) or R plus ERN and then crossed over to the alternative treatment. At the end of each treatment period, postprandial metabolic studies were performed and apoB-48 kinetics were determined.

The researchers found that the apoB-48 concentration was lower with ERN versus statin alone (P = 0.03). ERN treatment also correlated with significantly lower postprandial triglyceride and apoB-48 area under the curve (AUC; P < 0.05), with no change seen in triglyceride and apoB-48 incremental AUC. ERN treatment was associated with lower apoB-48 secretion rate (SR) in the basal state (P = 0.04) and a lower number of apoB-48 containing particles secreted in response to fat load (P = 0.02). ERN was not associated with alteration in apoB-48 fractional catabolic rates (P = 0.79).

"ERN reduces apoB-48 concentration by lowering fasting and postprandial apoB-48 SR," the authors write. "This effect may be beneficial for lowering atherogenic postprandial lipoproteins and may provide cardiovascular disease risk benefit in patients with type 2 diabetes."

One author disclosed financial ties to Abbott, which provided the ERN for the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »