Exposure to Metformin In Utero Ups Risk of Being Overweight

Share this content:
Exposure to Metformin In Utero Ups Risk of Being Overweight
Exposure to Metformin In Utero Ups Risk of Being Overweight

THURSDAY, March 1, 2018 (HealthDay News) -- Children exposed to metformin in utero have an increased risk of being overweight at age 4 years, according to research published online Feb. 27 in the Journal of Clinical Endocrinology and Metabolism.

Liv Guro Engen Hanem, M.D., from the Norwegian University of Science and Technology in Trondheim, and colleagues conducted follow-up to two randomized, double blind, placebo-controlled studies exploring the effects of metformin use on 182 offspring of pregnant women with polycystic ovary syndrome. Children's growth was assessed to 4 years of age. Height, weight, body mass index (BMI), and overweight/obesity at age 4, and head circumference were converted to z-scores.

The researchers found that at age 4 years there was a non-significant difference in height z-scores between children of women randomized to placebo and those randomized to metformin. However, at 4 years of age, the metformin group had a higher weight z-score than the placebo group (P = 0.017) and a higher BMI z-score (P = 0.010). In the metformin group, there were more overweight/obese children compared to the placebo group (P = 0.038).

"Metformin exposed children had higher BMI and increased prevalence of overweight/obesity at 4 years of age," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Vit D Independently, Inversely Tied to Cholesterol in Children

Vit D Independently, Inversely Tied to Cholesterol in ...

Gene variants do not modify the associations of 25(OH)D with lipids

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Lower degree of susceptibility to ibalizumab for nine of 10 patients with virology failure, rebound

Weight Gain After Quitting Smoking May Up T2DM Risk

Weight Gain After Quitting Smoking May Up T2DM ...

But temporary increase in type 2 diabetes risk does not attenuate benefits on total, CVD mortality

is free, fast, and customized just for you!




Already a member?

Sign In Now »