Experimental Gel Antibiotic May Offer New Otitis Media Rx

Share this content:
Experimental Gel Antibiotic May Offer New Otitis Media Rx
Experimental Gel Antibiotic May Offer New Otitis Media Rx

THURSDAY, Sept. 15, 2016 (HealthDay News) -- A single application of an antibiotic gel into the ear might one day offer an easier way to treat bacterial otitis media, according to an experimental study published online Sept. 14 in Science Translational Medicine.

A pentablock copolymer poloxamer 407-polybutylphosphoester was designed for smooth application followed by formation of a mechanically strong hydrogel on the tympanic membrane, where ciprofloxacin is slowly released over a week. The research team demonstrated its effectiveness in a chinchilla model of nontypable Haemophilus influenzae.

The otitis media infection was eradicated in all 10 chinchillas who received the new gel, while 62.5 percent of those receiving 1 percent ciprofloxacin alone had cleared the infection by day seven. The team found no evidence of ciprofloxacin systemically with the new system.

"The hydrogel system was biocompatible in the ear, and ciprofloxacin was undetectable systemically (in blood), confirming local drug delivery and activity," the authors write. "This fast-gelling hydrogel could improve compliance, minimize side effects, and prevent systemic distribution of antibiotics in one of the most common pediatric illnesses, possibly minimizing the development of antibiotic resistance."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

60 Percent of Adults Report Adverse Childhood Experiences

>60 Percent of Adults Report Adverse Childhood Experiences

Higher ACE exposures for black, Hispanic, multiracial individuals, those with below high school education

Few Yogurt Products Qualify As Low-Sugar

Few Yogurt Products Qualify As Low-Sugar

Only two of 101 children's yogurt and fromage frais products had ≤5 g sugar/100 g of product

Allopurinol Dose Escalation for Gout Doesn't Improve Mortality

Allopurinol Dose Escalation for Gout Doesn't Improve Mortality

Linked to small increase in mortality; at 2 years, 31 percent of dose escalators achieved serum urate goal

is free, fast, and customized just for you!




Already a member?

Sign In Now »