Exercise Prevents Diet-Induced Cell Senescence in Adipose Tissue

This article originally appeared here.
Share this content:
Exercise Prevents Diet-Induced Cell Senescence in Adipose Tissue
Exercise Prevents Diet-Induced Cell Senescence in Adipose Tissue

MONDAY, March 21, 2016 (HealthDay News) -- A novel mechanism has been proposed for the role of exercise in mitigating the detrimental impact of a fast-food diet (FFD) in mice, via prevention of cellular senescence, according to an experimental study published March 16 in Diabetes.

Marissa J. Schafer, Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues examined the extent to which diet and exercise affect the behavior and accretion of senescent cells within distinct tissues. Using transgenic mice that express enhanced green fluorescent protein (EGFP) in response to activation of the senescence-associated p16INK4a promoter, the authors examined whether exercise prevents senescent cell accumulation and systemic metabolic dysfunction induced by a FFD.

The researchers demonstrated that FFD consumption caused deleterious changes in body weight and composition, and in measures of physical, cardiac, and metabolic health. FFD correlated with increases in several markers of senescence, including p16, EGFP, senescence-associated β-galactosidase, and the senescence-associated secretory phenotype (SASP), specifically in visceral adipose tissue. Exercise was found to prevent the accumulation of senescent cells and SASP expression. Following long-term FFD-feeding, exercise correlated with reductions in senescent phenotype markers in visceral adipose tissue, and attenuated physical impairments.

"These findings highlight a novel mechanism by which exercise mediates its beneficial effects and reinforce the impact of modifiable lifestyle choices on health span," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »