Exercise-Induced Capillary Density Ups Insulin Sensitivity

This article originally appeared here.
Share this content:
Exercise-Induced Capillary Density Ups Insulin Sensitivity
Exercise-Induced Capillary Density Ups Insulin Sensitivity

FRIDAY, June 19, 2015 (HealthDay News) -- Exercise training is associated with an increase in skeletal muscle capillary density (CD), which contributes to improvements in glucose metabolism, according to a study published online June 11 in Diabetes.

Steven J. Prior, Ph.D., from the University of Maryland School of Medicine in Baltimore, and colleagues examined whether increases in skeletal muscle CD contribute to exercise-induced improvements in whole-body insulin sensitivity (M/I). Twelve previously sedentary older men and women underwent six months of aerobic exercise training followed by a two-week detraining period.

The researchers found that exercise training correlated with significant increases in maximal oxygen uptake, CD, and M/I (all P < 0.05). There were also increases in insulin activation of glycogen synthase (60 percent), glucose transporter-4 expression (16 percent), and 5' AMP-activated protein kinase-α1 expression (21 percent) with exercise training; after detraining, these reverted to baseline levels. CD and M/I remained elevated after detraining (18 and 15 percent, respectively: P < 0.05). In regression analysis, there was a direct correlation between the changes in M/I with changes in CD.

"These results suggest that an increase in CD is one mechanism contributing to sustained improvements in glucose metabolism after aerobic exercise training," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Zika, West Nile Cases Reported in Alabama

Zika, West Nile Cases Reported in Alabama

State health officials note that Zika hasn't been transmitted locally

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Increased suicide risk with one, two, and three or more medical contacts for traumatic brain injury

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP ...

Proportion achieving target BP increased with use of triple combo pill versus usual care at six months

is free, fast, and customized just for you!




Already a member?

Sign In Now »