Enoxaparin Prevents VTEs in Advanced Pancreatic Cancer

This article originally appeared here.
Share this content:
Enoxaparin Prevents VTEs in Advanced Pancreatic Cancer
Enoxaparin Prevents VTEs in Advanced Pancreatic Cancer

(HealthDay News) -- For patients with advanced pancreatic cancer (APC), enoxaparin is effective for prevention and treatment of venous thromboembolic events (VTEs), according to a study published online May 18 in the Journal of Clinical Oncology.

Uwe Pelzer, M.D., Ph.D., from Universitätsmedizin Berlin, and colleagues randomized 312 patients with histologically proven APC to ambulant first-line chemotherapy and prophylactic use of enoxaparin (160 patients) or chemotherapy alone (152 patients).

The researchers found that within the first three months there were 15 symptomatic VTEs in the observation group and two in the enoxaparin group (hazard ratio, 0.12; 95 percent confidence interval [CI], 0.03 to 0.52; P = 0.001). There were five major bleeding events in the observation group and seven in the enoxaparin group (hazard ratio, 1.4; 95 percent CI, 0.35 to 3.72; P = 1.0). The overall cumulative incidence rates of symptomatic VTEs were 15.1 and 6.4 percent for the observation and enoxaparin groups, respectively (hazard ratio, 0.40; 95 percent CI, 0.19 to 0.83; P = 0.01). There were no significant between-group differences noted in progression-free (hazard ratio, 1.06; 95 percent CI, 0.84 to 1.32; P = 0.64) and overall survival (hazard ratio, 1.01; 95 percent CI, 0.87 to 1.38; P = 0.44).

"This study demonstrates the high efficacy and feasibility of primary pharmacologic prevention of symptomatic VTEs in outpatients with APC," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Amgen, Eli Lilly, and sanofi-aventis, which provided enoxaparin free of charge.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »