Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A

Share this content:
Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A
Emicizumab Prophylaxis Cuts Bleeding in Hemophilia A

WEDNESDAY, Aug. 29, 2018 (HealthDay News) -- For patients with hemophilia A without factor VIII inhibitors, emicizumab prophylaxis leads to a significantly reduced bleeding rate, according to a study published in the Aug. 30 issue of the New England Journal of Medicine.

Johnny Mahlangu, M.B., B.Ch., from the University of Witwatersrand in Johannesburg, and colleagues randomized patients with hemophilia A without factor VIII inhibitors to receive a subcutaneous maintenance dose of emicizumab of 1.5 mg/kg of body weight/week (group A), 3 mg/kg every two weeks (group B), or no prophylaxis (group C) in a phase 3 multicenter trial. Participants who had been receiving factor VIII prophylaxis received emicizumab at a maintenance dose of 1.5 mg/kg/week (group D). There were 152 patients enrolled.

The researchers found that the annualized bleeding rate was 1.5 and 1.3 events in groups A and B, respectively, compared with 38.2 events in group C; the rate was 96 and 97 percent lower in groups A and B, respectively. Overall, 56 and 60 percent of participants in groups A and B, respectively, had no treated bleeding events, compared with group C, all of whom had treated bleeding events. In the intraindividual comparison involving 48 participants in group D, the annualized bleeding rate was 68 percent lower with emicizumab prophylaxis compared with the rate with previous factor VIII prophylaxis.

"Emicizumab prophylaxis administered subcutaneously once weekly or every two weeks led to a significantly lower bleeding rate than no prophylaxis among persons with hemophilia A without inhibitors," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including F. Hoffmann-La Roche and Chugai Pharmaceutical, which manufacture emicizumab and funded the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »