Efavirenz Doesn't Up Depression, Suicidal Ideation in HIV-Infected

Share this content:
Efavirenz Doesn't Up Depression, Suicidal Ideation in HIV-Infected
Efavirenz Doesn't Up Depression, Suicidal Ideation in HIV-Infected

MONDAY, June 25, 2018 (HealthDay News) -- For persons living with HIV (PLHIV) in Uganda, use of efavirenz is not associated with increased risk of depression or suicidal ideation, according to a study published online June 26 in the Annals of Internal Medicine.

Jonathan L. Chang, M.P.H., from the Duke University School of Medicine in Durham, N.C., and colleagues estimated the correlations between efavirenz use and depression and suicidal ideation among 694 PLHIV in Uganda in a prospective observational cohort study from 2005 to 2015.

Participants contributed 1,200 person-years of observation (460 person-years receiving efavirenz). The researchers found that depression or suicidal ideation did not differ at baseline for patients ever exposed to efavirenz versus those never exposed to efavirenz and receiving nevirapine. On at least one follow-up visit, depression and suicidal ideation were reported in 20.0 and 6.2 percent, respectively, of the 305 participants ever-exposed to efavirenz, compared with 32.1 and 12.1 percent, respectively, of the 389 patients who received nevirapine. Efavirenz use correlated with reduced odds of depression compared with nevirapine (adjusted odds ratio, 0.62; 95 percent confidence interval, 0.40 to 0.96), in adjusted generalized estimating equations, while there was no significant correlation for efavirenz with suicidal ideation (adjusted odds ratio, 0.61; 95 percent confidence interval, 0.30 to 1.25).

"No evidence was found that use of efavirenz in first-line antiretroviral therapy increased the risk for depression or suicidal ideation compared with nevirapine use among PLHIV in Uganda," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Many Americans May Have Prediabetes and Not Know It

CDC: Many Americans May Have Prediabetes and Not ...

AMA, CDC launch a campaign to raise awareness about prediabetes

Low-Carbohydrate Diets Linked to Increase in Calories Burned

Low-Carbohydrate Diets Linked to Increase in Calories Burned

Total energy expenditure is greater for those on a low- or moderate-carb diet during weight-loss maintenance

Many Patients Do Not Engage Health Care Provider During MS Relapse

Many Patients Do Not Engage Health Care Provider ...

Only half of patients reported always engaging health care providers

is free, fast, and customized just for you!




Already a member?

Sign In Now »