Dual-Hormone System May Lower Time in Hypoglycemia in T1DM

Share this content:
Dual-Hormone System May Lower Time in Hypoglycemia in T1DM
Dual-Hormone System May Lower Time in Hypoglycemia in T1DM

TUESDAY, May 15, 2018 (HealthDay News) -- For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia, according to a study published online May 11 in Diabetes Care.

Jessica R. Castle, M.D., from the Oregon Health & Science University in Portland, and colleagues enrolled 20 participants with type 1 diabetes. Participants underwent dual-hormone, single-hormone, predictive low glucose suspend, and continuation of current care over four days in a randomized order. Three moderate-intensity aerobic exercise sessions were included in each arm.

The researchers found that the lowest mean time in hypoglycemia was seen with dual-hormone during the exercise period (3.4 percent versus 8.3 [P = 0.009], 7.6 [P < 0.001], and 4.3 percent [P = 0.49] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire four-day study, time in hypoglycemia was also lowest with dual-hormone (1.3 percent versus 2.8 [P < 0.001), 2.0 [P = 0.04], and 3.1 percent [P = 0.007] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire study, time in range was the highest with single-hormone (74.3 percent, versus 72.0 percent with dual-hormone; P = 0.44).

"The addition of glucagon delivery to a closed-loop system with automated exercise detection reduces hypoglycemia in physically active adults with type 1 diabetes," the authors write.

Two authors disclosed financial ties to Pacific Diabetes Technologies.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »