Drug Combo Reduces Polyps in Familial Adenomatous Polyposis

This article originally appeared here.
Share this content:
Drug Combo Reduces Polyps in Familial Adenomatous Polyposis
Drug Combo Reduces Polyps in Familial Adenomatous Polyposis

TUESDAY, March 22, 2016 (HealthDay News) -- For patients with familial adenomatous polyposis (FAP), treatment with a combination of sulindac and erlotinib is associated with significant reductions in the number and diameter of polyps, according to a study published in the March 22/29 issue of the Journal of the American Medical Association.

N. Jewel Samadder, M.D., from the University of Utah in Salt Lake City, and colleagues examined the effect of the combination of sulindac and erlotinib on duodenal adenoma regression in 92 patients with FAP. Participants were randomized to sulindac twice daily and erlotinib daily (46 patients) or placebo (46 patients) for six months.

The second preplanned interim analysis met the prespecified stopping rule for superiority, and consequently the trial was stopped by the external data and safety monitoring board. The researchers found that the sulindac-erlotinib group had significant reductions in the median duodenal polyp burden (sum of the diameters of polyps) and polyp count (both P < 0.001). The sulindac-erlotinib group more often had grade 1 and 2 adverse events, with an acne-like rash seen in 87 and 20 percent of patients receiving treatment and placebo, respectively (P < 0.01). Two patients experienced grade 3 adverse events.

"Further research is necessary to evaluate these preliminary findings in a larger study population with longer follow-up to determine whether the observed effects will result in improved clinical outcomes," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »