Disrupted Sleep Linked to Increased Amyloid-β Production

This article originally appeared here.
Share this content:
Disrupted Sleep Linked to Increased Amyloid-β Production
Disrupted Sleep Linked to Increased Amyloid-β Production

WEDNESDAY, Dec. 13, 2017 (HealthDay News) -- Disrupted sleep is associated with increased amyloid-β production in adults, according to a study published online Dec. 8 in the Annals of Neurology.

Brendan P. Lucey, M.D., from the Washington University School of Medicine in St. Louis, and colleagues examined whether sleep disruption increases soluble amyloid-β using indwelling lumbar catheters to serially sample cerebrospinal fluid while eight participants (aged 30 to 60 years) were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. Amyloid-β kinetics were measured by infusion with 13C6-leucine.

The researchers found that, compared with controls who were allowed to sleep normally, sleep deprivation correlated with increased overnight amyloid-β-38, amyloid-β-40, and amyloid-β42 levels (25 to 30 percent increases).

"These findings suggest that disrupted sleep increases Alzheimer's disease risk via increased amyloid-β production," the authors write.

Several authors disclosed financial ties to C2N Diagnostics, including receiving royalties for patents and technology.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ground Beef Recalled After E. Coli Outbreak

Ground Beef Recalled After <i>E. Coli</i> Outbreak

Beef was produced and packaged at Cargill Meat Solutions in Fort Morgan, Colo.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060

Long-Term Outcomes of Breast Implants Explored

Long-Term Outcomes of Breast Implants Explored

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

is free, fast, and customized just for you!




Already a member?

Sign In Now »