Daylight Photodynamic Therapy Effective, Safe for Acne

This article originally appeared here.
Share this content:
Daylight Photodynamic Therapy Effective, Safe for Acne
Daylight Photodynamic Therapy Effective, Safe for Acne

WEDNESDAY, Dec. 23, 2015 (HealthDay News) -- Daylight photodynamic therapy with a novel variant of unsaturated ALA ester, 3-butenyl 5-aminolevulinate hydrochloride (ALA-bu), is effective and well tolerated for acne, according to a study published online Dec. 12 in the Journal of Dermatology.

Hyuck Hoon Kwon, M.D., from Seoul National University College of Medicine in South Korea, and colleagues examined the efficacy, safety, and histological changes of facial acne after application of 1.5 percent ALA-bu gel using daylight only as the potential visible light source. Participants included 46 patients with acne who were randomized to ALA-bu or vehicle applications. The allocated gel was applied to facial acne lesions every other day for 12 weeks.

The researchers found that both inflammatory and non-inflammatory lesions had decreased significantly in the ALA-bu group (58.0 and 34.1 percent, respectively) at the final week. Mild adverse events were only reported by a few patients. Attenuated inflammatory cell infiltrations were observed in the histopathological analysis; concomitant reductions were seen in immunostaining intensities for interleukin-8, interleukin-1β, matrix metalloproteinase-9, and phosphorylated nuclear factor ΚB. Comparable patterns were seen in changes of their mRNA expression.

"In conclusion, this ambulatory daylight photodynamic therapy was effective, very well tolerated, and convenient for treating inflammatory acne lesions," the authors write. "This novel regimen would provide a viable option for acne therapy."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Lyme-Bearing Ticks More Widespread in U.S. Than Thought

Lyme-Bearing Ticks More Widespread in U.S. Than Thought

Disease-carrying ticks were detected in 83 counties where they'd never been found before

Availability of Generic Antivirals for Hepatitis B Increasing

Availability of Generic Antivirals for Hepatitis B Increasing

Drop in median price of WHO-prequalified generic tenofovir from $208 to $32 from 2004 to 2016

Visual Function Deficits Up in Developmental Dyslexia

Visual Function Deficits Up in Developmental Dyslexia

Increased prevalence of deficits in visual function versus typically developing school-age children

is free, fast, and customized just for you!




Already a member?

Sign In Now »