Danazol Treatment Linked to Telomere Elongation

This article originally appeared here.
Share this content:
Danazol Treatment Linked to Telomere Elongation
Danazol Treatment Linked to Telomere Elongation

FRIDAY, May 20, 2016 (HealthDay News) -- In patients with telomere diseases, treatment with the synthetic sex hormone danazol is associated with telomere elongation, according to a study published in the May 18 issue of the New England Journal of Medicine.

Danielle M. Townsley, M.D., from the National Institutes of Health in Bethesda, Md., and colleagues conducted a phase 1-2 prospective study involving patients with telomere diseases. The synthetic sex hormone danazol was administered orally at a dose of 800 mg per day for 24 months, with a goal of attenuation of accelerated telomere attrition.

The study was stopped early after telomere attrition was reduced in all 12 patients who could be evaluated for the primary end point. The researchers found that in the intention-to-treat analysis, 12 of 27 patients met the primary efficacy end point (20 percent reduction in the annual rate of telomere attrition measured at 24 months). At 24 months, 11 of the 12 patients had a gain in telomere length compared with baseline; similar increases were seen at six and 12 months. Hematologic responses were seen for 79 and 83 percent of patients who could be evaluated at three and 24 months, respectively. Elevated liver-enzyme levels and muscle cramps of grade 2 or less occurred in 41 and 33 percent of the patients, respectively.

"In our study, treatment with danazol led to telomere elongation in patients with telomere diseases," the authors write.

Abstract
Full Text
Editorial

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Educational phone calls with nurses promote shared decision making in care

Early PT Linked to Less Opioid Use in Musculoskeletal Pain

Early PT Linked to Less Opioid Use in ...

For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain

Emotional Stress of Holidays Can Trigger Heart Attacks

Emotional Stress of Holidays Can Trigger Heart Attacks

Higher risk seen on Christmas Eve, particularly in older adults with diabetes, heart disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »