CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

Share this content:
CVD Risk Up With &#946;<sub>2</sub>-Agonist, Antimuscarinic Antagonist Start
CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

THURSDAY, Jan. 4, 2018 (HealthDay News) -- For patients with chronic obstructive pulmonary disease (COPD), new initiation of inhaled long-acting β2-agonists (LABAs) and long-acting antimuscarinic antagonists (LAMAs) is associated with increased risk of cardiovascular disease (CVD), according to a study published online Jan. 2 in JAMA Internal Medicine.

Meng-Ting Wang, Ph.D., from the National Defense Medical Center in Taipei, Taiwan, and colleagues conducted a nested case-control study involving LABA-LAMA-naive patients with COPD who were aged 40 years or older to examine the risk of CVD associated with LABAs and LAMAs. Data were included for 37,719 patients with CVD and 146,139 matched controls over a mean follow-up of two years.

The researchers found that in patients with COPD, new LABA and LAMA use was associated with a 1.5- and 1.52-fold increased cardiovascular risk within 30 days of initiation, respectively; with prevalent use, the risk was absent or reduced. CVD risk did not differ with individual LABA agents, LAMA dosage forms, and concomitant COPD regimens. In an alternative case-crossover study the risk persisted, and it remained across subgroups without history of CVD or prior exacerbations.

"New initiation of LABAs or LAMAs in patients with COPD is associated with an approximate 1.5-fold increased severe cardiovascular risk, irrespective of prior CVD status and history of exacerbations," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Bayer Stops U.S. Sale of Essure Birth Control Implant

Bayer Stops U.S. Sale of Essure Birth Control ...

Problems with device include chronic pain and perforations of the uterus and fallopian tubes

C.S. Mott Poll Addresses Child Safety at Amusement Parks

C.S. Mott Poll Addresses Child Safety at Amusement ...

2016 saw U.S. emergency departments deal with 30,000 injuries linked to amusement parks, carnivals

Greening Vacant Land Improves Neighborhood Mental Health

Greening Vacant Land Improves Neighborhood Mental Health

Cleaning up vacant lots in resource-limited urban settings can aid residents' mental health

is free, fast, and customized just for you!




Already a member?

Sign In Now »