CV Exercise Betters Cardiac Aging in Sedentary Middle-Aged Adults

Share this content:
CV Exercise Betters Cardiac Aging in Sedentary Middle-Aged Adults
CV Exercise Betters Cardiac Aging in Sedentary Middle-Aged Adults

MONDAY, Jan. 8, 2018 (HealthDay News) -- Two years of high-intensity exercise training (ExT) is associated with improved maximal oxygen uptake and reduced cardiac stiffness in previously sedentary healthy middle-aged adults, according to a study published online Jan. 8 in Circulation.

Erin J. Howden, Ph.D., from the Texas Health Presbyterian Hospital in Dallas, and colleagues randomized 61 healthy, sedentary, middle-aged participants to two years of ExT or attention control (control); 53 participants completed the study. Left ventricular (LV) end-diastolic pressure-volume relationships (EDPVR) and Frank-Starling curves were defined using right heart catheterization and three-dimensional echocardiography. Changes in fitness were quantified using maximal oxygen uptake.

The researchers found that there was 88 ± 11 percent adherence to prescribed exercise sessions. Maximal oxygen uptake increased by 18 percent (ExT: 34.4 ± 6.4; control: 28.7 ± 5.4; P < 0.001), while there was a reduction in LV stiffness in the ExT group (right/downward shift in the EDPVR: ExT: pre- to post-stiffness constant: 0.072 ± 0.037 to 0.051 ± 0.0268; P < 0.0018) but not in controls (pre- to post-stiffness constant: 0.0635 ± 0.026 to 0.062 ± 0.031; P = 0.83). LV end-diastolic volume was increased by exercise (P < 0.001), while there was no change in pulmonary capillary wedge pressure, resulting in greater stroke volume for any given filling pressure (P = 0.007).

"In previously sedentary healthy middle-age adults, two-years of exercise training improved maximal oxygen uptake and decreased cardiac stiffness," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Case Numbers of U.S. Children With Polio-Like Illness Hit Record High

Case Numbers of U.S. Children With Polio-Like Illness ...

CDC says there have been 158 confirmed cases of acute flaccid myelitis in 36 states

Paid Childbearing Policies Lacking for Residents

Paid Childbearing Policies Lacking for Residents

Policies optimizing competing goals and defining training competency needed

is free, fast, and customized just for you!




Already a member?

Sign In Now »