Cuts in Epilepsy Drugs Boost Children's Post-Op IQ

This article originally appeared here.
Share this content:
Cuts in Epilepsy Drugs Boost Children's Post-Op IQ
Cuts in Epilepsy Drugs Boost Children's Post-Op IQ

MONDAY, May 4, 2015 (HealthDay News) -- Withdrawal of antiepileptic drugs (AEDs) in children is tied to higher IQ post-epilepsy surgery, according to a study published online April 21 in the Annals of Neurology.

Kim Boshuisen, M.D., from the University Medical Center Utrecht in the Netherlands, and colleagues analyzed neuropsychological assessment data before and after epilepsy surgery for children participating in the TimeToStop study. The effect of AED withdrawal on postoperative IQ was assessed.

The researchers found that mean interval to latest neuropsychological assessment was 19.8 months. Reduction of AEDs significantly improved postoperative IQ and gain in IQ (adjusted regression coefficient [aRC], 3.4 [P = 0.018] and 4.5 [P = 0.002], respectively), as did complete withdrawal (aRC, 4.8 [P = 0.006] and 5.1 [P = 0.006], respectively). Decreased AEDs also predicted ≥10 points IQ increase (P = 0.019). After surgery, the higher the number of AEDs reduced, the higher the postoperative IQ and gain in IQ (IQ points per AED reduced: 2.2 [P = 0.007] and 2.6 [P = 0.001], respectively).

"Start of AED withdrawal, number of AEDs reduced, and complete AED withdrawal were associated with improved postoperative IQ scores and gain in IQ, independent of other determinants of cognitive outcome," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »