Corynebacterium, Kingella Abundance Tied to HNSCC Risk

Share this content:
<i>Corynebacterium</i>, <i>Kingella</i> Abundance Tied to HNSCC Risk
Corynebacterium, Kingella Abundance Tied to HNSCC Risk

FRIDAY, Jan. 12, 2018 (HealthDay News) -- The overall oral microbiome composition is not associated with the risk of head and neck squamous cell carcinoma (HNSCC), but greater abundance of genera Corynebacterium and Kingella is associated with decreased HNSCC risk, according to a study published online Jan. 11 in JAMA Oncology.

Richard B. Hayes, D.D.S., Ph.D., from the New York University School of Medicine in New York City, and colleagues conducted a nested case-control study in two prospective cohort studies to examine the correlation between the oral microbiome and incident HNSCC. A total of 129 patient cases of HNSCC were identified among 122,004 participants during an average follow-up of 3.9 years. Two controls were selected for each patient case (254 controls); cases and controls were similar in terms of age, sex, and race/ethnicity.

The researchers observed no correlation for overall microbiome composition with the risk of HNSCC. Decreased risk of HNSCC was seen in association with greater abundance of genera Corynebacterium (fold change, 0.58) and Kingella (fold change, 0.63), which was possibly related to carcinogen metabolism capacity. The correlations tended to be stronger for larynx cancer and for those with tobacco use history.

"This study demonstrates that greater oral abundance of commensal Corynebacterium and Kingella is associated with decreased risk of HNSCC, with potential implications for cancer prevention," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Increase Seen in Salmonella Illnesses From Ground Beef

CDC: Increase Seen in <i>Salmonella</i> Illnesses From Ground ...

246 people now sickened; 59 people have been hospitalized; no deaths reported to date

Epinephrine Personal Autoinjectors Cost-Effective at 24

Epinephrine Personal Autoinjectors Cost-Effective at &#36;24

Based on 10-fold fatality risk difference, value-based price for personal epinephrine $24

Burden of Liver Cancer Rising in Medicare Patients

Burden of Liver Cancer Rising in Medicare Patients

Coexistence of other liver conditions tied to even higher risk for death, health care costs

is free, fast, and customized just for you!




Already a member?

Sign In Now »