Coronary Artery Calcification Predicts 15-Year Mortality

Share this content:
Coronary Artery Calcification Predicts 15-Year Mortality
Coronary Artery Calcification Predicts 15-Year Mortality

(HealthDay News) -- For patients without symptoms of coronary artery disease, the extent of coronary artery calcification (CAC) predicts 15-year mortality, according to research published in the July 7 issue of the Annals of Internal Medicine.

Leslee J. Shaw, Ph.D., from the Emory University School of Medicine in Atlanta, and colleagues examined the ability of CAC scores to predict long-term mortality in an observational cohort study. CAC scoring and binary risk factor data were collected for 9,715 patients without symptoms of coronary artery disease. The primary end point was time to all-cause mortality; patients were followed for a median of 14.6 years.

The researchers found that the CAC score was highly predictive of all-cause mortality after adjustment for risk factors for coronary artery disease (P < 0.001). For CAC scores from 0 to 1,000 or greater, overall 15-year mortality rates ranged from 3 to 28 percent (P < 0.001). For all-cause mortality, the relative hazard ranged from 1.68 for a CAC score of 1 to 10 (P < 0.001) to 6.26 for a score of 1,000 or greater (P < 0.001). Using cut points of less than 7.5 percent to 22.5 percent or greater, the categorical net reclassification improvement was 0.21.

"Long-term estimates of mortality provide a unique opportunity to examine the value of novel biomarkers, such as CAC, in estimating important patient outcomes," the authors write.

Several study authors and journal editors disclosed financial ties to the pharmaceutical industry.

Full text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »