Continuous Therapy Improves Survival in Multiple Myeloma

This article originally appeared here.
Share this content:
Continuous Therapy Improves Survival in Multiple Myeloma
Continuous Therapy Improves Survival in Multiple Myeloma

MONDAY, Aug. 31, 2015 (HealthDay News) -- In patients with newly diagnosed multiple myeloma, novel agent-based continuous therapy (CT) significantly improves progression-free survival and overall survival (OS) compared with fixed duration of therapy (FDT), according to a study published online Aug. 17 in the Journal of Clinical Oncology.

Antonio Palumbo, M.D., from Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino in Italy, and colleagues analyzed data from patients with newly diagnosed myeloma enrolled in three phase III trials that randomly assigned patients to novel agent-based CT versus FDT.

The researchers found that over a median follow-up of 52 months, in the intent-to treat CT population (417 patients) versus the FDT population (410 patients), there were significant improvements in progression-free survival 1 (time from random assignment until the first progression or death; median, 32 versus 16 months; hazard ratio [HR], 0.47), progression-free survival 2 (time from random assignment until the second progression or death; median, 55 versus 40 months; HR, 0.61), and OS (four-year OS, 69 versus 60 percent; HR, 0.69).

"The improvement in progression-free survival 2 suggests that the benefit reported during first remission is not canceled by a shorter second remission. Progression-free survival 2 is a valuable end point to estimate long-term clinical benefit and should be included in future trials," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including to funders of the phase III trials.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Zika, West Nile Cases Reported in Alabama

Zika, West Nile Cases Reported in Alabama

State health officials note that Zika hasn't been transmitted locally

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Increased suicide risk with one, two, and three or more medical contacts for traumatic brain injury

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP ...

Proportion achieving target BP increased with use of triple combo pill versus usual care at six months

is free, fast, and customized just for you!




Already a member?

Sign In Now »