Continuous-Flow Production of Pharmaceuticals Feasible

Share this content:
Continuous-Flow Production of Pharmaceuticals Feasible
Continuous-Flow Production of Pharmaceuticals Feasible

FRIDAY, April 1, 2016 (HealthDay News) -- On-demand, continuous-flow synthesis and formulation of active pharmaceutical ingredients has been demonstrated in a compact reconfigurable system, according to a research article published in the April 1 issue of Science.

Andrea Adamo, Ph.D., from the Massachusetts Institute of Technology in Cambridge, and colleagues present an alternative approach to batch processing at multiple locations for pharmaceutical manufacturing.

The authors demonstrate continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis can be performed in a refrigerator-sized system, which is able to produce sufficient quantities to supply hundreds to thousands of oral or topical liquid diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride doses per day; these pharmaceuticals meet U.S. Pharmacopeia standards.

"Continuous manufacturing systems benefit from integrated processing and control, which can translate to increased safety (no manual handling) and shorter processing times," the authors write. "Realization and demonstration of good manufacturing practices and ultimately U.S. Food and Drug Administration approval will be critical to future applications of this technology, including production units for hospitals, health care organizations, pharmaceutical development, and humanitarian aid."

Several authors disclosed financial ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Educational phone calls with nurses promote shared decision making in care

Early PT Linked to Less Opioid Use in Musculoskeletal Pain

Early PT Linked to Less Opioid Use in ...

For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain

Emotional Stress of Holidays Can Trigger Heart Attacks

Emotional Stress of Holidays Can Trigger Heart Attacks

Higher risk seen on Christmas Eve, particularly in older adults with diabetes, heart disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »