Closed-Loop Insulin Delivery Promising in T1DM Pregnancy

Share this content:
Closed-Loop Insulin Delivery Promising in T1DM Pregnancy
Closed-Loop Insulin Delivery Promising in T1DM Pregnancy

FRIDAY, March 16, 2018 (HealthDay News) -- For pregnant women with type 1 diabetes, a closed-loop system is associated with comparable glucose control and significantly less hypoglycemia than sensor-augmented pump (SAP) therapy, according to a study published online March 13 in Diabetes Care.

Zoe A. Stewart, from the University of Cambridge in the United Kingdom, and colleagues recruited 16 pregnant women to an open-label randomized trial. Participants completed 28 days of closed-loop and SAP insulin delivery separated by a washout period; for up to six weeks postpartum, participants could continue to use the closed-loop system.

The researchers found that the proportion of time with glucose levels within target was comparable for the closed-loop and SAP insulin delivery periods (62.3 versus 60.1 percent). There was also no difference in the mean glucose (131.4 versus 131.4 mg/dL) and time spent hyperglycemic >140 mg/dL (36.6 versus 36.1 percent). Significantly fewer hypoglycemic episodes (median, 8.0 versus 12.5), and less time at <63 mg/dL (1.6 versus 2.7 percent) occurred during closed-loop; the rates of hypoglycemia <50 mg/dL (0.24 versus 0.47 percent) and low blood glucose index (1.0 versus 1.4) were significantly lower. During closed-loop therapy there was significantly less nocturnal hypoglycemia (1.1 versus 2.7 percent).

"Larger, longer duration multicenter trials are now indicated to determine clinical efficacy of closed-loop insulin delivery in T1D pregnancy and the impact on neonatal outcomes," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical device industries; several authors reported related patents and patent applications.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Bayer Stops U.S. Sale of Essure Birth Control Implant

Bayer Stops U.S. Sale of Essure Birth Control ...

Problems with device include chronic pain and perforations of the uterus and fallopian tubes

C.S. Mott Poll Addresses Child Safety at Amusement Parks

C.S. Mott Poll Addresses Child Safety at Amusement ...

2016 saw U.S. emergency departments deal with 30,000 injuries linked to amusement parks, carnivals

Greening Vacant Land Improves Neighborhood Mental Health

Greening Vacant Land Improves Neighborhood Mental Health

Cleaning up vacant lots in resource-limited urban settings can aid residents' mental health

is free, fast, and customized just for you!




Already a member?

Sign In Now »