Chewing Ticagrelor Loading Dose May Be Beneficial in STEMI

Share this content:
Chewing Ticagrelor Loading Dose May Be Beneficial in STEMI
Chewing Ticagrelor Loading Dose May Be Beneficial in STEMI

THURSDAY, Oct. 26, 2017 (HealthDay News) -- For patients with ST-segment elevation myocardial infarction (STEMI), chewing a loading dose (LD) of ticagrelor facilitates better early platelet inhibition, according to a study published online Oct. 25 in JAMA Cardiology.

Elad Asher, M.D., M.H.A., from Sheba Medical Center in Israel, and colleagues conducted a clinical trial involving 50 adult patients with STEMI who were randomized to chew an LD of ticagrelor (180 mg) or receive standard oral administration of the same dose.

The researchers found that at baseline, 30 minutes, and one and four hours after ticagrelor LD, the mean of P2Y12 reaction units in the chewing versus the standard group were 224 versus 219 (95 percent confidence interval [CI], −16.77 to 27.73; P = 0.26), 168 versus 230 (95 percent CI, −103.77 to −19.75; P = 0.003), 106 versus 181 (95 percent CI, −125.15 to −26.29; P = 0.005), and 43 versus 51 (95 percent CI, −36.34 to 21.14; P = 0.3), respectively. At 30 minutes after LD, platelet reactivity in the chewing group was reduced by 24 percent (95 percent CI, 19.75 to 103.77; P = 0.001). In the chewing versus the standard group, the relative inhibition of platelet aggregation was 51 versus 10 percent (95 percent CI, 13.69 to 67.67; P = 0.005) at one hour and 81 versus 76 percent (95 percent CI, −12.32 to 16.79; P = 0.24) at four hours.

"Larger studies are warranted to see if our preliminary findings translate into clinical outcomes," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »