Ceruloplasmin ID'd As Marker of Kidney Disease in Sickle Cell

This article originally appeared here.
Share this content:
Ceruloplasmin ID'd As Marker of Kidney Disease in Sickle Cell
Ceruloplasmin ID'd As Marker of Kidney Disease in Sickle Cell

MONDAY, Dec. 4, 2017 (HealthDay News) -- In patients with sickle cell anemia (SCA), urinary ceruloplasmin (CP) may complement urinary free hemoglobin as a noninvasive biomarker for chronic kidney disease (CKD), according to research published online Nov. 27 in the American Journal of Hematology.

Marina Jerebtsova, Ph.D., from Howard University in Washington, D.C., and colleagues conducted mass-spectrometry proteomic analysis on urine samples from patients with SCA and hemoglobinuria and high hemoglobin (six samples) and compared them to SCA control samples.

Of 270 proteins that were initially identified, the researchers found that 48 were significantly up- or down-regulated in the samples with hemoglobinuria (P < 0.0001). Subsequently, 18 extracellular proteins were focused on, including CP, a protein involved in iron metabolism. In SCA samples with hemoglobinuria, CP was present at much higher levels than that seen in SCA controls (P = 1.8 × 10 −5).

"Despite the increased urinary levels of CP, transferrin, and ferritin in the urine of SCA patients, only urinary CP demonstrated overall good correlations with CKD stage and urinary hemoglobin levels and represent a plausible noninvasive biomarker of CKD risk in SCA patients," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »