Carotid Fluoro-2-Doxyglucose Uptake Predicts CV Events

Share this content:
Carotid Fluoro-2-Doxyglucose Uptake Predicts CV Events
Carotid Fluoro-2-Doxyglucose Uptake Predicts CV Events

FRIDAY, July 17, 2015 (HealthDay News) -- For asymptomatic adults, carotid fluoro-2-deoxyglucose (FDG) uptake is a predictor of cardio-cerebrovascular events, according to a study published online July 15 in JACC: Cardiovascular Imaging.

Seung Hwan Moon, M.D., from the Samsung Medical Center in Seoul, South Korea, and colleagues examined the role of FDG as an independent prognostic indicator and whether it improves risk prediction beyond the Framingham risk score (FRS) and carotid intima-media thickness (CIMT). Carotid FDG uptake and CIMT were measured in 1,089 asymptomatic adults who underwent positron emission tomography/computed tomography imaging.

The researchers found that during an average follow-up of 4.2 years, cardio-cerebrovascular events occurred in 19 participants (1.74 percent). High carotid FDG uptake and high CIMT were independent predictors of events, in multivariable analyses (hazard ratios, 2.98 and 2.82, respectively). Adding carotid FDG uptake, but not CIMT, to FRS correlated with a significant increase in the time-dependent area under the receiver operating characteristic curve (AUC) from 0.60 to 0.73 (P = 0.04). The AUC was increased from 0.65 to 0.75 by adding carotid FDG uptake to FRS plus CIMT (P = 0.07). Addition of carotid FDG uptake to FRS and FRS plus CIMT also improved net reclassification for event prediction.

"High carotid FDG uptake predicts cardiovascular events independent of traditional risk factors and CIMT in asymptomatic adults, and may add to risk stratification beyond FRS and CIMT," the authors write.

The study was funded by a grant from the Samsung Biomedical Research Institute.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ancient Gene Protects Elephants From Cancer

Ancient Gene Protects Elephants From Cancer

The LIF6 gene destroys cells with damaged DNA

Reasons for Undergoing Cosmetic Procedures Explored

Reasons for Undergoing Cosmetic Procedures Explored

Psychological and emotional motivations more likely in patients wanting acne scar tx, tattoo removal

DNR Orders Linked to Increased Mortality in Older Adults

DNR Orders Linked to Increased Mortality in Older ...

Early versus late DNR tied to shorter median length of stay in hospitalized adults aged 65 years and older

is free, fast, and customized just for you!




Already a member?

Sign In Now »