Cardiorespiratory Fitness, White Matter Integrity Tied to Cognition

Share this content:
Cardiorespiratory Fitness, White Matter Integrity Tied to Cognition
Cardiorespiratory Fitness, White Matter Integrity Tied to Cognition

THURSDAY, Feb. 22, 2018 (HealthDay News) -- Cardiorespiratory fitness (CRF) is associated with better white matter (WM) fiber integrity in patients with mild cognitive impairment (MCI), according to a study published recently in the Journal of Alzheimer's Disease.

Kan Ding, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues examined the correlations of CRF measured by maximal oxygen uptake (VO2max) with WM fiber integrity and neurocognitive performance. The correlation was assessed in 81 participants (aged 65 ± 7 years), including 26 cognitively normal adults and 55 amnestic MCI patients.

The researchers observed no difference in global WM fiber integrity and VO2max for cognitively normal older adults and MCI patients. There was a positive correlation for VO2max with diffusion tensor imaging (DTI) metrics of fractional anisotropy in about 54 percent of WM fiber tracts, and a negative correlation with mean and radial diffusivities in about 46 and about 56 percent, respectively, of the WM fiber tracts. After adjustment for age, sex, body mass index, WM lesion burden, and MCI status, the correlations of VO2max with DTI metrics remained significant. In MCI patients, the DTI metrics obtained from the area that correlated with VO2max correlated with executive function performance.

"Higher levels of CRF are associated with better WM fiber integrity, which in turn is correlated with better executive function performance in MCI patients," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wait Times Have Improved in VA Health Care System

Wait Times Have Improved in VA Health Care ...

Wait times similar to private sector in 2014 but shorter overall and in some specialties in 2017

Medication Treatment for Substance Abuse Up in Facilities

Medication Treatment for Substance Abuse Up in Facilities

2007 to 2016 saw increase in use of medication treatment, reaching 36.1 percent in 2016

Mindfulness, Stress Linked to Menopausal Symptoms

Mindfulness, Stress Linked to Menopausal Symptoms

Link between mindfulness and symptoms more robust in women experiencing higher stress

is free, fast, and customized just for you!




Already a member?

Sign In Now »