Calculated LDL-C Varies at Lower Values of Measured LDL-C

This article originally appeared here.
Share this content:
Calculated LDL-C Varies at Lower Values of Measured LDL-C
Calculated LDL-C Varies at Lower Values of Measured LDL-C

MONDAY, Aug. 10, 2015 (HealthDay News) -- At lower values of measured low-density lipoprotein cholesterol (LDL-C), the variation and bias of calculated LDL-C increases, according to a study published in the Aug. 15 issue of The American Journal of Cardiology.

Noting that the Friedewald equation for calculation of LDL-C is the primary laboratory method for routine LDL-C measurement, Jeffrey W. Meeusen, Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues compared the accuracy and reproducibility of calculated LDL-C <130 mg/dL to LDL-C measured by β quantification (considered the gold standard). The comparison was conducted in 15,917 patients with fasting triglyceride concentrations <400 mg/dL.

The researchers found that at lower values of measured LDL-C, variation and bias of calculated LDL-C increased. For a calculated LDL-C of 70 mg/dL and 30 mg/dL, the 95 percent confidence intervals were 60 to 86 mg/dL and 24 to 60 mg/dL, respectively.

"Calculated LDL-C <30 mg/dL (0.8 mmol/L) should not be reported because of significant deviation from the gold standard measured LDL-C results, and caution is advised when using calculated LDL-CF values <70 mg/dL (1.8 mmol/L) to make treatment decisions," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »