Biomarker Score May Help Predict Response to Cancer Treatment

Share this content:
Biomarker Score May Help Predict Response to Cancer Treatment
Biomarker Score May Help Predict Response to Cancer Treatment

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Fourteen genes have been identified that may help determine whether a cancer treatment could help a patient, according to a study published online Aug. 31 in Nature Communications.

The researchers first determined 14 genes that consistently over-express in a large number of cancers. The study team then created a scoring system (Centromere and kinetochore gene Expression Score [CES]) based on the degree of over-expression. A higher score meant more over-expression in those genes.

For several types of major cancers, the higher the score, the worse the prognosis for patients. But "another finding -- one that is counterintuitive -- is that high expression of these genes is also related to more effective chemotherapy and radiation therapy," said principal investigator Gary Karpen, Ph.D., a senior scientist at the U.S. Department of Energy's Lawrence Berkeley National Laboratory in California. The scores could then lead to predicting patient response to specific cancer treatments, according to the study team.

"Our results demonstrate the prognostic and predictive power of the CES, suggest a role for centromere misregulation in cancer progression, and support the idea that tumors with extremely high chromosomal instability are less tolerant to specific genotoxic therapies," the authors conclude.

Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Ad Campaign Hopes to Halt E-Cigarette Use Among Teens

FDA Ad Campaign Hopes to Halt E-Cigarette Use ...

'The Real Cost' Youth E-Cigarette Prevention Campaign to target at-risk youth

U.S. Senate Passes Opioids Bill

U.S. Senate Passes Opioids Bill

Comprehensive bipartisan package earmarks billions of dollars to fight opioid abuse in the United States

Active Choice Intervention Tied to Increase in Flu Shot Rates

Active Choice Intervention Tied to Increase in Flu ...

Vaccination rates decrease throughout the day; with intervention, similar increase throughout day

is free, fast, and customized just for you!




Already a member?

Sign In Now »