BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

Share this content:
BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes
BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

THURSDAY, June 21, 2018 (HealthDay News) -- The Bacillus Calmette Guérin (BCG) vaccine is associated with a reduction in hyperglycemia among patients with type 1 diabetes with long-term disease, according to a study published online June 21 in npj Vaccines.

Willem M. Kühtreiber, Ph.D., from Harvard Medical School in Boston, and colleagues reported on a randomized eight-year-long prospective examination of type 1 diabetes subjects with long-term disease who received two BCG vaccine doses.

The researchers found that BCG lowered hemoglobin A1c to near-normal levels after year 3 for the next five years. A novel systemic and blood sugar-lowering mechanism drove the BCG impact on blood sugars in diabetes. A systemic shift was observed in glucose metabolism from oxidative phosphorylation to aerobic glycolysis. Metabolomics, mRNAseq, and functional assays of cellular glucose uptake after BCG vaccinations confirmed this finding. Murine data demonstrated a reduction in blood sugars and aerobic induction in non-autoimmune mice that were made chemically diabetic. Six central T-regulatory genes for genetic reprogramming of tolerance were reset with BCG via epigenetics.

"These findings set the stage for further testing of a known safe vaccine therapy for improved blood sugar control through changes in metabolism and durability with epigenetic changes even in advanced type 1 diabetes," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Bayer Stops U.S. Sale of Essure Birth Control Implant

Bayer Stops U.S. Sale of Essure Birth Control ...

Problems with device include chronic pain and perforations of the uterus and fallopian tubes

C.S. Mott Poll Addresses Child Safety at Amusement Parks

C.S. Mott Poll Addresses Child Safety at Amusement ...

2016 saw U.S. emergency departments deal with 30,000 injuries linked to amusement parks, carnivals

Greening Vacant Land Improves Neighborhood Mental Health

Greening Vacant Land Improves Neighborhood Mental Health

Cleaning up vacant lots in resource-limited urban settings can aid residents' mental health

is free, fast, and customized just for you!




Already a member?

Sign In Now »