Azathioprine Appears to Improve Disease Course in Early Crohn's

This article originally appeared here.
Share this content:
Azathioprine Appears to Improve Disease Course in Early Crohn's
Azathioprine Appears to Improve Disease Course in Early Crohn's

MONDAY, Oct. 2, 2017 (HealthDay News) -- Long-term use of azathioprine (AZA) is associated with a better disease course in patients with early Crohn's disease (CD), according to a study published online Sept. 22 in the Journal of Gastroenterology and Hepatology.

Yun Qiu, from Sun Yat-sen University in China, and colleagues evaluated the impact of AZA on disease progression in a cohort of 190 patients with early CD (disease duration ≤18 months) and no previous use of disease-modifying agents.

The researchers found that over a median follow-up of 57 months, 31 patients underwent abdominal surgeries, 48 patients were hospitalized, and 68 patients experienced clinical flares. The cumulative rate of remaining free of CD-related bowel surgery, hospitalization, and flares after five years on AZA treatment was 0.65, 0.59, and 0.39, respectively. Prior bowel resection (hazard ratio [HR], 9.23; smoking (HR, 4), and hemoglobin <110 g/L at the time of initiation of AZA (HR, 4.36) were independent predictors of CD-related operations. AZA treatment duration >36 months (HR, 0.04) was associated with reduced CD-related operations.

"Prolonged use of AZA was associated with a more favorable disease course of early CD, evident as a lower risk of CD-related surgery," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Identifies Drugs Frequently Involved in Drug Overdose Deaths

CDC Identifies Drugs Frequently Involved in Drug Overdose ...

Oxycodone, heroin, and fentanyl ranked first in 2011, 2012-2015, 2016; cocaine ranked second or third

2017 Saw Slowing in National Health Care Spending

2017 Saw Slowing in National Health Care Spending

Slower growth in health care spending mainly due to use and intensity of goods and services

Inflammatory Bowel Disease, Prostate Cancer Linked

Inflammatory Bowel Disease, Prostate Cancer Linked

At age 60, men with inflammatory bowel disease have higher values of prostate-specific antigen

is free, fast, and customized just for you!




Already a member?

Sign In Now »