Automated Bone Scan Index Prognostic for Prostate Cancer

Share this content:
Automated Bone Scan Index Prognostic for Prostate Cancer
Automated Bone Scan Index Prognostic for Prostate Cancer

TUESDAY, July 3, 2018 (HealthDay News) -- The automated Bone Scan Index (aBSI) is an independent prognostic imaging biomarker of overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC), according to a study published online May 17 in JAMA Oncology.

Andrew J. Armstrong, M.D., from Duke University in Durham, N.C., and colleagues conducted a prospectively defined analysis of the aBSI in a randomized clinical trial to assess the index as an independent prognostic determinant of OS. Participants included men with bone metastatic chemotherapy-naive CRPC recruited at 241 sites in 37 countries. A total of 1,245 men were enrolled, of whom 721 were evaluable for the aBSI.

The researchers observed a significant correlation for the aBSI with OS (hazard ratio, 1.2). By aBSI quartile (lowest to highest), the median OS was 34.7, 27.3, 21.7, and 13.3 months, respectively. Compared with manual lesion counting, the aBSI had significantly higher discriminative ability in prognosticating OS (C-index, 0.63 versus 0.6). A higher aBSI remained independently associated with OS in a multivariable survival model (hazard ratio, 1.06). There were also independent, significant correlations for a higher aBSI with time to symptomatic progression and time to opiate use for cancer pain (hazard ratios, 1.18 and 1.21).

"These data support the prognostic utility of the aBSI as an objective imaging biomarker in the design and eligibility of clinical trials of systemic therapies for patients with mCRPC," the authors write.

Several authors disclosed financial ties to biotechnology companies, including EXINI Diagnostics AB and Active Biotech AB, which provided funding for the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »