Atezolizumab Effective in Late-Stage Non-Small-Cell Lung Cancer

Share this content:
Atezolizumab Effective in Late-Stage Non-Small-Cell Lung Cancer
Atezolizumab Effective in Late-Stage Non-Small-Cell Lung Cancer

TUESDAY, Dec. 13, 2016 (HealthDay News) -- The immunotherapy atezolizumab extends the survival of previously treated non-small-cell lung cancer patients for several months and causes fewer side effects than docetaxel, according to a study published online Dec. 12 in The Lancet.

The findings are from an early open-label analysis of 850 patients with squamous or non-squamous non-small-cell lung cancer in a phase 3 trial. The participants received either atezolizumab or docetaxel. Patients had previously received one to two cytotoxic chemotherapy regimens for stage IIIB or IV non-small-cell lung cancer.

According to a team led by David Gandara, M.D., of the University of California, Davis Comprehensive Cancer Center, patients who took atezolizumab survived for an average of 13.8 months, compared with 9.6 months for those on docetaxel. Patients taking atezolizumab also had lower rates of severe side effects. Fifteen percent experienced grade 3 or 4 adverse events while on atezolizumab, compared to 43 percent of those on docetaxel.

"This is the first phase 3 trial of a programmed death-ligand 1 [PD-L1]-directed immunotherapy in lung cancer," Gandara said in a journal news release. "The fact that it improves survival in patients with all categories of PD-L1 expression is highly encouraging and adds to the already known benefits of immunotherapy in lung cancer."

The study was funded by F. Hoffmann-La Roche and Genentech; Genentech is the manufacturer of atezolizumab.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »