April 2018 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for April 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Similar Risk Predicted for Automated, Clinical BI-RADS Density

MONDAY, April 30, 2018 (HealthDay News) -- Automated and clinical Breast Imaging Reporting and Data System (BI-RADS) density measures similarly predict breast cancer risk, according to a study published online May 1 in the Annals of Internal Medicine.

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Five Healthy Lifestyle Habits Could Add >10 Years to Life

MONDAY, April 30, 2018 (HealthDay News) -- Adopting a healthy lifestyle, with five low-risk lifestyle factors is associated with increased life expectancy, according to a study published online April 30 in Circulation.

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Liver-Kidney Recipients Have Donor-Specific Hypo-Responses

MONDAY, April 30, 2018 (HealthDay News) -- Simultaneous liver-kidney transplant recipients' peripheral blood cells have unique phenotypic and functional characteristics that are associated with donor-specific hypo-alloresponsiveness, according to a study published online April 12 in Kidney International.

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Checklist Developed for Parents of Children With Cancer

MONDAY, April 30, 2018 (HealthDay News) -- A standardized, time-sensitive checklist can help guide the education process for parents of children newly diagnosed with cancer, according to an article published online March 28 in the Journal of Pediatric Oncology Nursing.

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Art Intervention May Be Beneficial for Cancer Patients

FRIDAY, April 27, 2018 (HealthDay News) -- A bedside visual art intervention may help with cancer patients' pain, anxiety, and mood, according to a study published online April 17 in the European Journal of Cancer Care.

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New Clinic Satisfaction Tool Provides Real-Time Feedback

THURSDAY, April 26, 2018 (HealthDay News) -- A new clinic satisfaction tool improves communication and provides real-time feedback, according to a study published online April 14 in Neurosurgery.

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Sickle Cell Trait Not Linked to Stroke in African-Americans

FRIDAY, April 27, 2018 (HealthDay News) -- For African-Americans, sickle cell trait (SCT) seems not to be associated with the incidence of ischemic stroke, according to a meta-analysis published online April 23 in JAMA Neurology.

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Spermatogenesis Still Occurs in Men With Testicular Cancer

FRIDAY, April 27, 2018 (HealthDay News) -- Spermatogenesis occurs in most men with testicular cancer, often away from tumors, according to a study published online April 17 in BJU International.

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Knowledge Not Tied to Addictive Tanning Behavior in Millennials

FRIDAY, April 27, 2018 (HealthDay News) -- For millennials, sun protection knowledge is not associated with addictive tanning behavior, according to a recent study published in the Journal of Consumer Affairs.

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Potentially Inappropriate Meds Use Prevalent in Cancer Patients

FRIDAY, April 27, 2018 (HealthDay News) -- Potentially inappropriate medication (PIM) use is relatively prevalent among patients with breast or colorectal cancer, though it is not associated with most adverse outcomes, according to a study published online April 24 in Cancer.

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Improvement in Race-Based Disparities in Years of Life Lost

THURSDAY, April 26, 2018 (HealthDay News) -- From 1990 to 2014 there was a decrease in race-based disparities in years of life lost (YLL) in the United States, according to a study published online April 25 in PLOS ONE.

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Pros and Cons for E-Cigarettes As Aid to Smoking Cessation

THURSDAY, April 26, 2018 (HealthDay News) -- Evidence relating to the pros and cons of electronic cigarettes (e-cigarettes) as helpful smoking cessation tools is presented and discussed in a head to head article published online April 25 in The BMJ.

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Multiple Myeloma Risk May Be Up for WTC-Exposed Firefighters

THURSDAY, April 26, 2018 (HealthDay News) -- World Trade Center-exposed firefighters have increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and light-chain MGUS, which are precursors to multiple myeloma, as well as an increased cancer burden, according to two studies published online April 26 in JAMA Oncology.

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Saturday Is National Prescription Drug Take Back Day

THURSDAY, April 26, 2017 (HealthDay News) -- The U.S. Drug Enforcement Administration and local agencies are holding the 15th National Prescription Drug Take Back Day across the country this Saturday, April 28.

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Proactive Swallowing Rehab Program Helpful in Phalangeal CA

THURSDAY, April 26, 2018 (HealthDay News) -- A proactive speech and language pathology (SLP) program is beneficial for patients with head and neck squamous cell carcinoma (HNSCC), according to a study published online April 19 in JAMA Otolaryngology-Head & Neck Surgery.

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Medicare Requiring Hospitals to Post Prices Online

WEDNESDAY, April 25, 2018 (HealthDay News) -- U.S. hospitals will have to post their standard prices online and make it easier for patients to access their electronic medical records, Medicare officials said Tuesday.

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Alcohol Intake May Influence Oral Microbiome Composition

TUESDAY, April 24, 2018 (HealthDay News) -- Alcohol consumption, specifically heavy drinking, may influence the oral microbiome composition, according to a study published online April 24 in Microbiome.

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Flexible Sigmoidoscopy Cuts CRC Incidence, Mortality in Men

MONDAY, April 23, 2018 (HealthDay News) -- Flexible sigmoidoscopy screening is associated with reduced colorectal cancer (CRC) incidence and mortality in men, but not women, according to a study published online April 24 in the Annals of Internal Medicine.

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Patients Prefer Doctors Who Engage in Face-to-Face Visits

MONDAY, April 23, 2018 (HealthDay News) -- Patients prefer physicians who engage in face-to-face (F2F) clinic visits, rather than those using an examination room computer (ERC), according to a research letter published online April 19 in JAMA Oncology.

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Cancer Screening More Likely After a Previous False Positive

MONDAY, April 23, 2018 (HealthDay News) -- Patients who previously had a false-positive breast or prostate cancer screening test result are more likely to have future screenings, according to a study published online April 23 in Cancer.

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Celecoxib Lowers Opioid Use Post Head & Neck Cancer Surgery

MONDAY, April 23, 2018 (HealthDay News) -- For patients undergoing head and neck cancer (HNC) surgery, perioperative use of celecoxib is associated with reduced use of opioids after surgery, according to a study published online April 18 in JAMA Otolaryngology-Head & Neck Surgery.

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PAs May Have Lower Diagnostic Accuracy for Melanoma

FRIDAY, April 20, 2018 (HealthDay News) -- Physician assistants (PAs) perform more skin biopsies per case of skin cancer diagnosed and diagnose fewer melanomas in situ than dermatologists, according to a study published online April 18 in JAMA Dermatology.

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Colon Cancer Survival Varies by Insurance Type

FRIDAY, April 20, 2018 (HealthDay News) -- Compared to patients with private insurance, colon cancer survival is lower for patients with no insurance or with Medicaid, according to a study published in the May issue of Diseases of the Colon & Rectum.

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Most Smokers With Head and Neck Cancer Have Tried to Quit

THURSDAY, April 19, 2018 (HealthDay News) -- Most active smokers with head and neck squamous cell carcinoma (HNSCC) have made one or more quit attempts, according to a study published online April 12 in JAMA Otolaryngology-Head & Neck Surgery.

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Gene Therapy Found to Be Promising for β-Thalassemia

THURSDAY, April 19, 2018 (HealthDay News) -- For patients with severe β-thalassemia, the need for red-cell transfusions can be reduced or eliminated by transducing cells with the LentiGlobin BB305 vector, according to a study published in the April 18 issue of the New England Journal of Medicine.

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Cellular Biomedical Tattoo Can ID Hypercalcemia-Linked Cancer

WEDNESDAY, April 18, 2018 (HealthDay News) -- A cell-based biomedical tattoo can detect hypercalcemia associated with cancer in a murine model, according to an experimental study published in the April 18 issue of Science Translational Medicine.

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Marital Status Tied to Earlier Presentation of Melanoma

WEDNESDAY, April 18, 2018 (HealthDay News) -- For patients with localized melanoma, marital status is associated with earlier presentation, according to a study published online April 18 in JAMA Dermatology.

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New Drug Combo Ups Survival in HER2/neu Uterine Serous Cancer

WEDNESDAY, April 18, 2018 (HealthDay News) -- For patients with human epidermal growth factor receptor 2 (HER2)/neu-positive uterine serous carcinoma, adding intravenous trastuzumab to treatment with carboplatin-paclitaxel is associated with increased progression-free survival, according to a study published online March 27 in the Journal of Clinical Oncology.

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Polypharmacy More Likely for Cancer Survivors

WEDNESDAY, April 18, 2018 (HealthDay News) -- Cancer survivors are more likely to be prescribed five or more unique medications, including drugs with abuse potential, according to a study published online April 12 in Cancer.

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Calcium Channel Blockers May Up Pancreatic Cancer Risk in Women

TUESDAY, April 17, 2018 (HealthDay News) -- Use of short-acting calcium channel blockers (CCBs) is associated with increased risk of pancreatic cancer in postmenopausal women, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 14 to 18 in Chicago.

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Males With BRCA Mutations Have Increased Risk of Certain Cancers

TUESDAY, April 17, 2018 (HealthDay News) -- Males with BRCA mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers, according to a research letter published online April 12 in JAMA Oncology.

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Recommendations Developed on Gender Equity in Medicine

MONDAY, April 16, 2018 (HealthDay News) -- In a position paper published online April 17 in the Annals of Internal Medicine, recommendations are provided aimed at addressing gender equity in physician compensation and career advancement opportunities.

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TFs Operate Across Gene Loci Within Disease Phenotypes

MONDAY, April 16, 2018 (HealthDay News) -- Transcription factors (TFs) seem to operate across gene loci, according to a study published online April 16 in Nature Genetics.

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Volumetric Laser Endomicroscopy Helps ID Barrett's Regions

MONDAY, April 16, 2018 (HealthDay News) -- Volumetric laser endomicroscopy (VLE) users can identify regions of interest for potential Barrett's esophagus (BE) dysplasia with a high degree of agreement, according to a study published online April 6 in the Journal of Gastroenterology and Hepatology.

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Nonoptimized Drug Therapy Costs More Than $500 Billion Annually

MONDAY, April 16, 2018 (HealthDay News) -- The estimated annual cost of drug-related morbidity and mortality resulting from nonoptimized medication therapy is more than half a trillion dollars in the United States, according to a study published online March 26 in the Annals of Pharmacotherapy.

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Negative Affect That Lingers Tied to Health 10 Years Later

FRIDAY, April 13, 2018 (HealthDay News) -- Negative affect that lingers is associated with worse physical health outcomes almost 10 years later, according to a study published online March 19 in Psychological Science.

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Adherence to ACS Guidelines Linked to Survival in Colon Cancer

FRIDAY, April 13, 2018 (HealthDay News) -- Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors (ACS guidelines) is associated with improved survival for patients with stage III colon cancer, according to a study published online April 12 in JAMA Oncology.

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Recent Years Saw Increase in Burden of Prior Authorization

THURSDAY, April 12, 2018 (HealthDay News) -- The burden of prior authorization (PA) has increased over the past five years, and 92 percent of physicians report associated delays in access to care, according to the results of a survey published by the American Medical Association (AMA).

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Quality of Life Predicts Mortality in Older Breast Cancer Patients

THURSDAY, April 12, 2018 (HealthDay News) -- For older women with early-stage breast cancer, measures of health-related quality of life (HRQOL) predict 10-year mortality independently of traditional breast cancer prognostic variables, according to a study published online March 13 in the Journal of the American Geriatrics Society.

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No Higher Cancer Risk Seen for Heart Failure Patients

THURSDAY, April 12, 2018 (HealthDay News) -- Heart failure is not associated with an increased risk of cancer, according to a study published in the April 10 issue of the Journal of the American College of Cardiology.

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FDA Warning Ups Hysterectomy Complications for Uterine Fibroids

THURSDAY, April 12, 2018 (HealthDay News) -- For women undergoing hysterectomy for uterine fibroids, there was an increase in major and minor 30-day complication rates following the issuing of a U.S. Food and Drug Administration black box warning against the use of power morcellation for excision of uterine fibroids, according to a study published online April 11 in JAMA Surgery.

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Endocrine Therapy-Induced Alopecia Seen in Breast Cancer

THURSDAY, April 12, 2018 (HealthDay News) -- For patients with breast cancer, endocrine therapy-induced alopecia (EIA) has a pattern that is similar to androgenetic alopecia, according to a study published online April 11 in JAMA Dermatology.

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Cigarette Price Hike Would Provide More Gains for the Poor

THURSDAY, April 12, 2018 (HealthDay News) -- An increase in the market prices of cigarettes would provide more health and financial gains to the poorest 20 percent of the population, according to a study published online April 11 in The BMJ.

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Increased Prevalence of Depression, Anxiety After CRC

THURSDAY, April 12, 2018 (HealthDay News) -- The prevalence of depression and anxiety are increased among survivors of colorectal cancer (CRC), according to a study published online April 6 in Cancer.

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Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

WEDNESDAY, April 11, 2018 (HealthDay News) -- Gemcitabine and cisplatin (GC) plus ipilimumab is associated with a 69 percent objective response rate and 61 percent one-year overall survival for patients with metastatic urothelial cancer, according to a study published in the May issue of European Urology.

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Odds of Prescribing Drugs Up With Doc Receipt of Payments

WEDNESDAY, April 11, 2018 (HealthDay News) -- Physicians receiving general payments from pharmaceutical companies are more likely to prescribe their drugs, according to a research letter published online April 9 in JAMA Internal Medicine.

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Suggestions Offered to Reduce Physician Frustration With EHRs

TUESDAY, April 10, 2018 (HealthDay News) -- Changes can be implemented to help reduce physician frustration with electronic health records (EHRs), according to an article published in Medical Economics.

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Considerable Differences in Burden of Disease at State Level

TUESDAY, April 10, 2018 (HealthDay News) -- There are considerable differences in the burden of disease at the state level, according to a study published in the April 10 issue of the Journal of the American Medical Association.

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Group Exercise, Nutrition Aids Prostate Cancer Patients on ADT

TUESDAY, April 10, 2018 (HealthDay News) -- Men on androgen-deprivation therapy (ADT) for prostate cancer may significantly benefit from a group exercise and nutrition program, according to a study published online March 5 in the Annals of Behavioral Medicine.

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Most Patients Are Unaware of Drug Cancer Shortages

MONDAY, April 9, 2018 (HealthDay News) -- Most people in the United States are unaware of national cancer drug shortages, according to a study published online April 9 in Cancer.

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Interns' Schedule Takes Toll on Sleep, Physical Activity, Mood

FRIDAY, April 6, 2018 (HealthDay News) -- New interns' intense and changing schedules take a toll on sleep, activity, and mood, according to a study published online March 14 in the Journal of General Internal Medicine.

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Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

FRIDAY, April 6, 2018 (HealthDay News) -- Myocarditis in patients treated with immune checkpoint inhibitors (ICIs) may be more common than previously thought, according to a study published online March 19 in the Journal of the American College of Cardiology.

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Leukemia, and Its Treatment, May Pose Neurocognitive Risks

FRIDAY, April 6, 2018 (HealthDay News) -- Underlying leukemia, even before chemotherapy, may pose a neurocognitive risk to young patients, according to a study published online March 29 in JAMA Oncology.

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ACA Marketplaces Expand Coverage for Chronically Ill

THURSDAY, April 5, 2018 (HealthDay News) -- The Affordable Care Act's Marketplaces covered a disproportionate share of non-elderly adults with high health care risks in the 2014 to 2015 time period, according to a study published in the April issue of Health Affairs.

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Online Doc Reviews Don't Reflect Patient Satisfaction Surveys

THURSDAY, April 5, 2018 (HealthDay News) -- Online physician reviews do not reflect patient satisfaction surveys (PSSs), according to a study published in the April issue of the Mayo Clinic Proceedings.

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mRNA Assay Less Sensitive Than DNA Assay for Latent HPV

THURSDAY, April 5, 2018 (HealthDay News) -- The human papillomavirus (HPV) mRNA assays are less sensitive than HPV DNA assays for detection of latent HPV infection, according to a study published online March 8 in Obstetrics & Gynecology.

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Few Indoor Tanners Have Been Screened for Skin Cancer

THURSDAY, April 5, 2018 (HealthDay News) -- About 30 percent of indoor tanners (ITs) have been screened for skin cancer (SC), with correlates of screening including older age, history of melanoma or SC, and use of very high sun protection factor (SPF) sunscreen use, according to a study published online April 4 in JAMA Dermatology.

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Metabolic Abnormalities Seen in Testicular Cancer Survivors

WEDNESDAY, April 4, 2018 (HealthDay News) -- Testicular cancer survivors (TCS) have metabolic abnormalities characterized by hypertension and increased low-density lipoprotein (LDL) and total cholesterol, according to a study published in the March 1 issue of the Journal of the National Comprehensive Cancer Network.

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Variations Identified in Free-Text Directions in E-Prescriptions

WEDNESDAY, April 4, 2018 (HealthDay News) -- There is considerable variation in the quality of free-text patient directions (Sig) in electronic prescriptions (e-prescriptions), according to a study published online April 2 in the Journal of Managed Care & Specialty Pharmacy.

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Breast Cancer Diagnosis, Therapy Differ in Women With Implants

WEDNESDAY, April 4, 2018 (HealthDay News) -- Method of diagnosis, stage, and treatment are not affected by type of breast implant or anatomic location, according to research published in the April issue of Plastic and Reconstructive Surgery.

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Overweight, Obesity Contributing to Cancers in Young Adults

TUESDAY, April 3, 2018 (HealthDay News) -- Overweight and obesity may be contributing to specific malignancies at younger ages, according to research published online March 23 in Obesity.

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Radiation Oncology Missing in Medical School Education

MONDAY, April 2, 2018 (HealthDay News) -- A small number of academic-affiliated radiation oncology (RO) departments report involvement with formal teaching of medical students, according to a study published recently in the Journal of the American College of Radiology.

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Thyroidectomy Rates Lower After Guideline Implementation

MONDAY, April 2, 2018 (HealthDay News) -- Implementation of the 2015 American Thyroid Association guidelines on surgery for well-differentiated thyroid carcinoma was associated with a significant decrease in the rates of both up-front total thyroidectomy and completion thyroidectomy, according to a study published online March 29 in JAMA Otolaryngology-Head & Neck Surgery.

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