Antidepressant Efficacy Varies for Depressive Symptom Clusters

Share this content:
Antidepressant Efficacy Varies for Depressive Symptom Clusters
Antidepressant Efficacy Varies for Depressive Symptom Clusters

TUESDAY, Feb. 28, 2017 (HealthDay News) -- Antidepressant treatment efficacy varies for empirically-defined clusters of symptoms, according to a study published online Feb. 22 in JAMA Psychiatry.

Adam M. Chekroud, from Yale University in New Haven, Conn., and colleagues determined the efficacy of antidepressant treatments on empirically defined groups of symptoms. Data on patients with depression from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were used to identify clusters of symptoms. These findings were replicated using the Combining Medications to Enhance Depression Outcomes (CO-MED) trial. Using intent-to-treat data for the 4,706 patients from both trials, the authors examined whether observed symptom clusters have differential response trajectories; data were also included for 2,515 additional placebo and active-comparator phase 3 trials of duloxetine.

The researchers found that at baseline, there were three symptom clusters identified in the self-reported Quick Inventory of Depressive Symptomatology scale in STAR*D, which was replicated in CO-MED and was similar for the clinician-rated Hamilton Depression rating scale. Eight of nine antidepressants were more effective for core emotional symptoms than for sleep or atypical symptoms. Between-drug differences in efficacy were often greater than the difference between treatments and placebo.

"Selecting the best drug for a given cluster may have a bigger benefit than that gained by use of an active compound versus a placebo," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical Trial

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical ...

Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis

Education Can Up Emotional Intelligence in Residents

Education Can Up Emotional Intelligence in Residents

Increase in total EI median scores, stress management composite score after intervention

Cancer-Related Gene Variations Frequently Reclassified

Cancer-Related Gene Variations Frequently Reclassified

24.9 percent of variants of uncertain significance were reclassified at a single commercial laboratory

is free, fast, and customized just for you!




Already a member?

Sign In Now »