Anticonvulsants Seem to Be Ineffective for Low Back Pain

Share this content:
Anticonvulsants Seem to Be Ineffective for Low Back Pain
Anticonvulsants Seem to Be Ineffective for Low Back Pain

THURSDAY, July 5, 2018 (HealthDay News) -- Anticonvulsant drugs are ineffective for chronic low back pain and can cause harm, despite a recent increase in prescribing, according to a review published online July 3 in CMAJ, the journal of the Canadian Medical Association.

Oliver Enke, M.B.B.S., from the University of Sydney, and colleagues conducted a literature review to identify studies comparing an anticonvulsant (topiramate, gabapentin, or pregabalin) to placebo in patients with non-specific low back pain, sciatica, or neurogenic claudication.

Based on nine studies (859 unique participants), the researchers found that in 14 out of 15 comparisons, anticonvulsants were not effective for reducing pain or disability in low back pain or lumbar radicular pain. Specifically, there was high-quality evidence of no effect of gabapentinoids versus placebo on chronic low back pain in the short term (pooled mean difference [MD], 0.0) or for lumbar radicular pain in the immediate term (pooled MD, 0.1). However, there was a high level of evidence of increased risk of adverse events from use of gabapentinoids.

"We have shown, with mostly high- and moderate-quality evidence, that common anticonvulsants are ineffective for chronic low back pain and lumbar radicular pain, and are accompanied by increased risk of adverse events," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

8 More U.S. Communities to Be Assessed for PFAS Toxin Exposure

8 More U.S. Communities to Be Assessed for ...

Assessments will lay groundwork for future study of the health effects of perfluoroalkyl, polyfluoroalkyl

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

Proposed rule will help consumers better understand what the sunscreens they are buying can actually do

U.S. Agencies Probing Johnson  Johnson Over Asbestos in Talc

U.S. Agencies Probing Johnson & Johnson Over Asbestos ...

Company has faced lawsuits linking its body powders with ovarian cancer or mesothelioma

is free, fast, and customized just for you!




Already a member?

Sign In Now »