Antenatal Metformin Cuts Maternal Weight Gain in Obese

Share this content:
Antenatal Metformin Cuts Maternal Weight Gain in Obese
Antenatal Metformin Cuts Maternal Weight Gain in Obese

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- For obese women, metformin administration during pregnancy is associated with reduced maternal weight gain, without reducing median neonatal birth weight, according to a study published in the Feb. 4 issue the New England Journal of Medicine.

Argyro Syngelaki, Ph.D., from King's College Hospital in London, and colleagues randomized pregnant women without diabetes with a body mass index (BMI) of >35 kg/m² to metformin or placebo (225 in each group) from 12 to 18 weeks of gestation until delivery. Data were analyzed for 202 women in the metformin group and 198 in the placebo group.

The researchers observed no significant difference in the median neonatal birth-weight z score between the groups (0.05 in the metformin group versus 0.17 in the placebo group; P = 0.66). Compared with the placebo group, the metformin group had lower median maternal gestational weight gain (4.6 versus 6.3 kg; P < 0.001) and lower incidence of preeclampsia (3.0 versus 11.3 percent; odds ratio, 0.24; P = 0.001). The metformin group had higher incidence of side effects compared with the placebo group. No significant differences were observed between the groups in the incidence of gestational diabetes, large-for-gestational-age neonates, or adverse neonatal outcomes.

"Among women without diabetes who had a BMI of more than 35, the antenatal administration of metformin reduced maternal weight gain but not neonatal birth weight," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves First Generic EpiPen

FDA Approves First Generic EpiPen

Approval will address both rising costs and shortages of epinephrine

Report Details Corneal Infection Tied to Sleeping in Contacts

Report Details Corneal Infection Tied to Sleeping in ...

Six patients reported sleeping in lenses on regular basis; most had vision loss, permanent damage

Honey May Protect Children Who Swallow Button Batteries

Honey May Protect Children Who Swallow Button Batteries

Honey and Carafate appear to rapidly protect against batteries' caustic effects

is free, fast, and customized just for you!




Already a member?

Sign In Now »