Anemia Criteria Assist Decision on Type of Colorectal Cancer Screen

Share this content:
Anemia Criteria Assist Decision on Type of Colorectal Cancer Screen
Anemia Criteria Assist Decision on Type of Colorectal Cancer Screen

THURSDAY, Jan. 3, 2019 (HealthDay News) -- In patients without broad-definition anemia and/or abdominal mass, flexible sigmoidoscopy (FS), instead of colonoscopy, may suffice to rule out colorectal cancer, according to a study published online Dec. 19 in the British Journal of Cancer.

Using hospital records and cancer registries, Amanda J. Cross, Ph.D., from Imperial College London, and colleagues followed 7,375 patients (≥55 years) with suspected colorectal cancer who were referred to 21 English hospitals (2004 to 2007). The authors sought to determine which patients could undergo FS instead of colonoscopy.

One hundred twenty-seven proximal and 429 distal colorectal cancers were diagnosed during the study period. The researchers found that a broad anemia definition (<13 g/dL in men and <12 g/dL in women) identified 80 percent of proximal cancers. A narrow definition of anemia (hemoglobin <11 g/dL in men and <10 g/dL in women) with iron-deficiency anemia identified 39 percent of proximal cancers. In patients with broad-definition anemia and/or abdominal mass, the proximal cancer yield was 4.8 percent and number of needed whole-colon examinations (NNE) to diagnose one cancer was 21. In patients without broad-definition anemia and/or abdominal mass but with rectal bleeding or increased stool frequency (41 percent of the cohort), proximal cancer yield was 0.4 percent and NNE was 234.

"In patients without broad definition anemia and/or abdominal mass, with rectal bleeding or increased stool frequency, proximal cancer is rare and FS should suffice," the authors write.

One author disclosed financial ties to PENTAX Medical, Olympus, Fujifilm, and Aquilant.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA: Gout Drug Uloric Increases Risk of Death

FDA: Gout Drug Uloric Increases Risk of Death

Medication is associated with increased risk of heart-related death and death from all causes

Since Early 2000s, Overdose Death Rates Are Highest in U.S.

Since Early 2000s, Overdose Death Rates Are Highest ...

U.S. was not an outlier in terms of drug overdose mortality prior to the early 2000s

National Health Spending Set to Increase 5.5 Percent Annually

National Health Spending Set to Increase 5.5 Percent ...

Long-observed demographic and economic factors expected to drive growth in health spending

is free, fast, and customized just for you!




Already a member?

Sign In Now »